Surviving Sepsis After Burn Campaign

Greenhalgh, David G.; Hill, David M.; Burmeister, David M.; Gus, Eduardo; Cleland, Heather; Padiglione, Alex; Holden, Dane; Huss, Fredrik; Chew, Michelle; Kubasiak, John; Burrell, Aidan; Manzanares, William; Gómez, María Chacón; Yoshimura, Yuya; Sjöberg, Folke; Xie, Weiguo; Egipto, Paula; Lavrentieva, Athina; Jain, Arpana; Miranda-Altamirano, Ariel; Raby, Edward; Aramendi, I.; Sen, Soman; Chung, Kevin K.; Alvarez, Renata Jennifer Quintana; Han, Chunmao; Matsushima, Asako; Elmasry, Moustafa; Liu, Yan; Donoso, Carlos Segovia; Bolgiani, Alberto; Johnson, Laura S.; Vana, Luiz Philipe Molina; Romero, Rosario Valdez Duval de; Allorto, N.L.; Abesamis, Gerald M.; Luna, Virginia Nuñez; Gragnani, Alfredo; Gonzàles, Carolina Bonilla; Basílico, Hugo; Wood, Fiona; Jeng, James C.; Li, Andrew; Singer, Mervyn; Luo, Gaoxing; Palmieri, Tina L; Kahn, S.; Joe, Victor; Cartotto, Robert

doi:10.1016/j.burns.2023.05.003

Cited by 10 publications

(4 citation statements)

References 415 publications

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“…Diagnoses of sepsis and septic shock were based on the Sepsis-3 criteria 8 , supported by our institution's research indicating its effectiveness in diagnosing burn patients 9 . The findings from the Surviving Sepsis After Burn (SSABC) guidelines in the 2023 Burns journal further corroborate this choice 10 . CBC parameters were collected daily throughout each patient's ICU stay, focusing particularly on the week preceding sepsis or septic shock onset.…”

Section: Methodsmentioning

confidence: 61%

Big data insights into the diagnostic values of CBC parameters for sepsis and septic shock in burn patients: a retrospective study

Kim,

Kym,

Park

et al. 2024

Sci Rep

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Sepsis and septic shock are prevalent and life-threatening complications in burn patients. Despite their severity, existing diagnostic methods are limited. This study aims to evaluate the efficacy of Complete Blood Count (CBC) and CBC ratio markers in diagnosing sepsis and septic shock, and in predicting mortality among burn patients. A cohort of 2757 burn patients was examined to ascertain the correlation between various CBC parameters, their ratios, and the incidence of sepsis and related mortality. Key markers analyzed included Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Mean Platelet Volume-to-Platelet Ratio (MPVPR). Our findings indicate that 65.5% of the patients developed sepsis, and 24.3% succumbed to their conditions. The CBC parameters RDW, MPV, NLR, MPVPR, and MPV-to-Lymphocyte Ratio (MPVLR) were significantly associated with sepsis and mortality. These markers showed considerable temporal variation and yielded an Area Under the Curve (AUC) of over 0.65 in an unadjusted Generalized Estimating Equations (GEE) model. This study underscores the potential of RDW, MPV, NLR, MPVPR, and MPVLR as vital prognostic tools for diagnosing sepsis, septic shock, and predicting mortality in burn patients. Although based on a single-center dataset, our results contribute to the enhancement of sepsis management by facilitating earlier, more precise diagnosis and treatment strategies. Further multi-center research is necessary to confirm these findings and broaden their applicability, establishing a solid base for future explorations in this crucial field.

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Section: Methodsmentioning

confidence: 61%

Big data insights into the diagnostic values of CBC parameters for sepsis and septic shock in burn patients: a retrospective study

Kim,

Kym,

Park

et al. 2024

Sci Rep

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“…It is difficult to accurately diagnose burn-related sepsis since criteria included by the ABA and other society guidelines are like the systemic inflammatory response syndrome (SIRS) related to the burn injury itself. The Surviving Sepsis After Burns Campaign 2023 consensus explicitly recommends against the use of SIRS criteria to diagnose sepsis in burn patients [25]. A parameter such as serum PCT can be added to the current definitions of sepsis to augment the accuracy of making the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin in the Post-Operative Burn Patient

Masole,

Ede,

Muganza

2023

EBJ

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Serum procalcitonin (PCT) is a biomarker used to diagnose sepsis and infection. Following invasive bacterial infection, PCT is detectable in peripheral blood. The aim of our study was to determine if there is a relationship between serum PCT post-burn wound debridement and burn-related sepsis. In total, 34 participants were recruited from 1 November 2019 to 31 July 2020. Serum PCT levels were drawn on days 0, 1, 2, and 3, with day 0 being the day of the surgery. Blood culture samples were drawn on days 0 and 3. Statistical analyses were performed using STATA©. Descriptive statistics were presented as the median for continuous data and frequencies for categorical data. A two-sample Wilcoxon–Mann–Whitney test was performed to assess the correlation between the PCT values and blood culture positivity. In all, 33 burn debridement procedures were completed, and 1 patient demised before surgery. The median age was 35.5 years; 61.8% were male. Four patients had comorbidities. There was a trend of higher PCT values from day 0 to day 3. The median PCT on day 0 was 3.30 µg/L (IQR 0.78–15.10), compared to day 3 PCT which was 5.15 µg/L (IQR 1.35–18.55). The median values for serum PCT for days 0 to 3 were above the normal threshold regardless of BC positivity. There was a statistically significant difference in the PCT levels between positive and negative BC, with a p value of 0.0087 for day 3 serum PCT. The findings indicate an association of a high serum PCT level with a positive blood culture in a burn patient post-debridement surgery. A higher numerical threshold/cut-off of serum PCT should be used for this cohort of patients, to aid in the diagnosis of sepsis. A cut-off value could not be determined due to the small sample size.

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“… 88 , 89 In addition to disruption of the anatomic barrier, the combination of excessive inflammation and immunosuppression caused by DAMPs increases the mortality rate of sepsis in patients with severe burns. 89 The Surviving Sepsis After Burn Campaign guidelines, which were published in 2023, 90 provide 60 statements for guidance on 14 topics related to the early treatment of sepsis in burn patients.…”

Section: Acute and Late Complications Of Burnsmentioning

confidence: 99%

Systemic immune response of burns from the acute to chronic phase

Osuka,

Shigeno,

Matsuura

et al. 2024

Acute Medicine & Surgery

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Immune responses that occur following burn injury comprise a series of reactions that are activated in response to damaged autologous tissues, followed by removal of damaged tissues and foreign pathogens such as invading bacteria, and tissue repair. These immune responses are considered to be programmed in living organisms. Developments of modern medicine have led to the saving of burned patients who could not be cured previously; however, the programmed response is no longer able to keep up, and various problems have arisen. This paper describes the mechanism of immune response specific to burn injury and the emerging concept of persistent inflammation, immunosuppression, and catabolism syndrome.

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Surviving Sepsis After Burn Campaign

Cited by 10 publications

References 415 publications

Big data insights into the diagnostic values of CBC parameters for sepsis and septic shock in burn patients: a retrospective study

Big data insights into the diagnostic values of CBC parameters for sepsis and septic shock in burn patients: a retrospective study

Procalcitonin in the Post-Operative Burn Patient

Systemic immune response of burns from the acute to chronic phase

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