Susceptibilité d’Anopheles gambiae sensu lato aux insecticides communément utilisés dans la lutte antivectorielle au Mali

Abstract

The objective of this work was to monitor the susceptibility of malaria vectors to insecticides in nine sentinel sites of the National Malaria Control Program in Mali. The study was performed during the rainy seasons of 2010 and 2011. WHO bioassays were conducted using F0 and/or F1 from wild collected females. The insecticides used were lambda-cyhalothrin 0.05%, DDT 4%, permethrin 0.75%, deltamethrin 0.05%, bendiocarb 0.1% and fenitrothion 1.0%. Results showed suspicion of resistance to pyrethroids and organochlorine in An. gambiae s.l. at almost all the sites except Yanfolila where the vector was susceptible to lambda-cyhalothrin (98.0%) [CI 95%, 98-99.8] and to DDT (100%). An. gambiae s.l. was susceptible to bendiocarb in five of the sites (Gao, Bougouni, Djenné, Yanfolila, Tombouctou) while there was a suspicion of resistance at the other sites (Kati, Niono, Bandiagara, Kita). Fenitrothion remains efficient except in the rice area of Niono, where there was a suspicion of resistance with a mortality rate of 92% [IC 95% 88.3-94.8]. Thus, it could be used as an alternative insecticide for IRS in Mali. These results show resistance to pyrethroids, the main insecticide family used in public health (and to some extent in agriculture). This could compromise the malaria vector control efforts in Mali where pyrethroids are used for both in bed nets and in IRS.

Performance of pirimiphos-methyl based Indoor Residual Spraying on entomological parameters of malaria transmission in the pyrethroid resistance region of Koulikoro, Mali.

“…Ten (10) other houses were randomly selected in each village as sentinel sites for EWT sampling. The EWT consisted of mounting on windows, traps which collected the mosquitoes entering the rooms ( Figure 2).…”

“…gambiae s.l. ), to insecticides, the fragile progress made in malaria control can be compromised [10]. The wide and long term use of pyrethroid insecticides in LLINs and the agricultural sector seems to be one of the main causes of the increasing resistance of malaria vector to these products [11,12].…”

Stratification At The Health District Level And Targeting of Malaria Control Interventions In Mali

“…The entomological data presented here includes data from 2010 to 2019, from Malaria Research and Training Center (MRTC) and NMCP partner (VectoLink) carried to the sentinel sites of the NMCP [5,6,20,21]. Two parameters were studied: vector distribution, vector resistance to insecticides, and their mechanism.…”

Performance of Indoor Residual Spray on entomological parameters of malaria transmission using pirimiphos-methyl in the context of pyrethroids resistance in Koulikoro region, Mali.

“…gambiae s.l.) to insecticides the fragile progress made in malaria control can be compromised [7]. The wide and long term uses of pyrethroid insecticides in LLINs and in agriculture seem to be one of the main cause of increasing vector resistance to these products [8,9].…”