Susceptibility and Comparative Pathology of Ten Species of Primates Exposed to Infection with Schistosoma Mansoni *

Sadun, E. H.; Lichtenberg, F. Von; Bruce, J. I.

doi:10.4269/ajtmh.1966.15.705

Cited by 50 publications

(23 citation statements)

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“…The bladder and ureters ofS. mansoni infection (Sadun et al, 1966). of these animals were, however, essentially These were spotting and brown discolora-normal.…”

Section: Parasitologymentioning

confidence: 99%

Effect of Schistosoma haematobium and N-butyl-N-(4-hydroxybutyl)nitrosamine on the development of urothelial neoplasia in the baboon

Hicks¹,

James²,

Webbe³

1980

Br J Cancer

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Summary.-Experiments were conducted to determine whether bladder cancer would develop in primates (Papio sp.) infected with S. haematobium and concurrently exposed to low initiating doses of the bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). To control for the systemic effects of schistosomiasis, 5 baboons were infected with S. mansoni, which does not lay its eggs in the bladder wall; to control for the effect of the carcinogen alone, 5 others were treated with BBN alone at the rate of 5 or 50 mg/kg per week for the duration of the experiment. Five animals were infected with S. haematobium and had no further treatment, and the main experimental group of 10 baboons was infected with S. haematobium and also treated weekly with 5 mg/kg BBN for up to 21 years. Four of the 10 animals in the last group, but none in the three control groups developed neoplastic disease of the urothelium. Four animals with S. haematobium plus BBN treatment developed in situ carcinoma in the bladder (3 latent adenomatous lesions and 1 more advanced papillary tumour) and 2 of these animals plus 1 other had slightly dysplastic urothelial endophytic papillary growths of the ureter which penetrated the muscle layer. By contrast, none of the control animals developed urothelial carcinomas, though 4/5 of those with S. haematobium infection alone had inflamed bladders with polypoid lesions, and one individual had endophytic papillary hyperplasia of the ureter. The animals were killed after 21 years while still relatively immature or adolescent, and it is possible that had they been allowed to survive longer some of the BBN-only group would have developed bladder cancer, and more of the latent lesions seen in the BBN + schistosomiasis group would have progressed to invasive carcinoma. It is postulated that, in this model for human bilharzial bladder cancer, schistosomiasis supplies the proliferative stimulus necessary to accelerate cancer growth from latent tumour foci produced by exposure to low doses of the bladder carcinogen. In areas of endemic schistosomiasis, carcinogenesis might be initiated, for example, by low doses of nitrosamines produced in the urinary tract during bouts of bacteriuria.

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“…The bladder and ureters ofS. mansoni infection (Sadun et al, 1966). of these animals were, however, essentially These were spotting and brown discolora-normal.…”

Section: Parasitologymentioning

confidence: 99%

Effect of Schistosoma haematobium and N-butyl-N-(4-hydroxybutyl)nitrosamine on the development of urothelial neoplasia in the baboon

Hicks¹,

James²,

Webbe³

1980

Br J Cancer

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“…(Sadun et al 1966, Warren & Simões 1966; 10: Tupaia sp. (Sadun et al 1966); 11: Saguinus fuscillis (subcutaneous, resistant to percutaneous infection, Portillo & Damian 1986); 12: Ateles geoffroyi (Sadun et al 1966); 13: Papio cynocephalus cynocephalus and P. c. anubis (Njenga et al 1998). …”

Section: General Considerations In the Interpretation Of Models Of Scmentioning

confidence: 99%

“…(Sadun et al 1970); 2a: Papio anubis (Sadun et al 1966, Mola et al 1999; 2b: Cercopithecus aethiops (Sadun et al 1966, Cheever & Duvall 1974; 3: Cebus apella (Sadun et al 1966, Barral et al 1983; 4: Macaca mulatta (Sadun et al 1966, Cheever & Powers 1969; 5: Aotus trivirgatus (Erickson et al 1971); 6: Macaca speciosa (Sadun et al 1966); 7: Macaca cynomolgus (Sadun et al 1966); 8: Saimiri sciureus (Sadun et al 1966); 9: Callithrix sp. (Sadun et al 1966, Warren & Simões 1966; 10: Tupaia sp. (Sadun et al 1966); 11: Saguinus fuscillis (subcutaneous, resistant to percutaneous infection, Portillo & Damian 1986); 12: Ateles geoffroyi (Sadun et al 1966); 13: Papio cynocephalus cynocephalus and P. c. anubis (Njenga et al 1998).…”

Section: General Considerations In the Interpretation Of Models Of Scmentioning

confidence: 99%

“…Passage in the molluscan host may also result in genetic selection of the worms (Richards & Shade 1987). (Sadun et al 1970); 2a: Papio anubis (Sadun et al 1966, Mola et al 1999; 2b: Cercopithecus aethiops (Sadun et al 1966, Cheever & Duvall 1974; 3: Cebus apella (Sadun et al 1966, Barral et al 1983; 4: Macaca mulatta (Sadun et al 1966, Cheever & Powers 1969; 5: Aotus trivirgatus (Erickson et al 1971); 6: Macaca speciosa (Sadun et al 1966); 7: Macaca cynomolgus (Sadun et al 1966); 8: Saimiri sciureus (Sadun et al 1966); 9: Callithrix sp. (Sadun et al 1966, Warren & Simões 1966; 10: Tupaia sp.…”

Section: General Considerations In the Interpretation Of Models Of Scmentioning

confidence: 99%

See 1 more Smart Citation

Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

123

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“…Sadun et al 41 also found signs of granuloma on four Callithrix aurita infected percutaneously with 50 (two animals) and 1000 (two other animals) cercariae of S. mansoni Puerto Rican strain. In this article, the authors investigated the percentage of adult worms recovered, localization and morphology of worms, the length of pre-patent period, number of eggs in the feces, number and localization of eggs in the tissue, egg viability, gross pathology and histopathology of organs such as lungs, liver, and intestines, and for the signs of other infections.…”

Section: Oliveira Al Et Almentioning

confidence: 98%