Susceptibility and resistance in leprosy: Studies in the mouse model

Adams, Linda B.

doi:10.1111/imr.12960

Cited by 20 publications

(11 citation statements)

References 120 publications

(177 reference statements)

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“…The former populations (Njombé and Kaélé) did not overexpress Cyp4g16 , but it could be that other enzymes, located upstream in the CHC biosynthetic machinery, are differentially expressed and affect the final amounts of the produced CHCs. Although CHCs abundance affect insecticide resistance levels [ 41 , 42 ] it has also been demonstrated that it could influence mating success [ 44 ]. CHCs genes alongside metabolic base resistance genes and target site resistance could contribute to the general profile of resistance detected in vector populations in Cameroon.…”

Section: Discussionmentioning

confidence: 99%

Pyrethroid Resistance Situation across Different Eco-Epidemiological Settings in Cameroon

et al. 2022

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Rapid emergence and spread of pyrethroid resistance in Anopheles gambiae populations is among the main factors affecting malaria vector control in Cameroon, but there is still not enough data on the exact pyrethroid resistance status across Cameroon. The present study assessed pyrethroid resistance profile in different eco-epidemiological settings in Cameroon. Susceptibility bioassay tests were performed with F0 An. gambiae females aged three to five days. Mosquito susceptibility to both permethrin and deltamethrin was assessed. Species of the An. gambiae s.l. complex were identified using molecular diagnostic tools. Target site mutations conferring resistance were detected using Taqman assays. Quantitative reverse transcription-real-time PCR (qRT-PCR) 3-plex TaqMan® assays were used for the quantification of detoxification genes implicated in pyrethroid resistance. An. gambiae, An. coluzzii and An. arabiensis were identified in the different settings. An. gambiae was dominant in Santchou, Kékem, Bélabo, Bertoua and Njombé, while An. coluzzii was abundant in Tibati and Kaélé. High frequencies of the kdr L1014F allele ranging from 43% to 100% were recorded in almost all sites. The L1014S kdr allele was detected at low frequency (4.10–10%) only in mosquito populations from Njombé and Tibati. The N1575Y mutation was recorded in Kaélé, Santchou, Tibati and Bertoua with a frequency varying from 2.10% to 11.70%. Six Cytochrome P450 genes (Cyp6p3, Cyp6m2, Cyp9k1, Cyp6p4, Cyp6z1, and Cyp4g16) were found to be overexpressed in at least one population. Analysis of cuticular hydrocarbon lipids indicated a significant increase in CHC content in mosquito populations from Kaélé and Njombé compared to Kékem, Bélabo and Bertoua populations. The study indicated high pyrethroid resistance across different ecological settings in Cameroon with different profile of resistance across the country. The present situation calls for further actions in order to mitigate the impact of insecticide resistance on vector control measures.

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Section: Discussionmentioning

confidence: 99%

Pyrethroid Resistance Situation across Different Eco-Epidemiological Settings in Cameroon

et al. 2022

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“…M. leprae has been detected in a wide variety of wild animals. Leprosy-like lesions have been reported in wild chimpanzees and sooty mangabey monkeys (Cercocebus atys) 18 , 19 . Armadillos infected with M. leprae are found in the southern United States and in South American countries and play a small role as reservoirs for the transmission of leprosy to humans 20 .…”

Section: Zero Leprosymentioning

confidence: 99%

Qua vadis leprosy?

Daniel

Ebenezer

2023

Indian Journal of Medical Research

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“…17 Mice is one of the most widely used experimental species for leprosy research. 16,17 Previous research has suggested that murine or mice could be used as a rodent model for leprosy because they recapitulate the clinical and histopathological spectrum of the disease, provide insights into immunoregulatory mechanisms, and can be used to test new drug therapies for leprosy. [16][17][18] Thus, this systematic review aims to review the use of the mice as an animal model for leprosy and to comprehensively review the pathogenesis, immunological responses and therapeutic interventions of leprosy based on animal studies.…”

Section: Introductionmentioning

confidence: 99%

Utilization of Mice as Hansen Disease Models for Comprehensive Analysis of Pathogenesis, Immunological Responses, and Therapeutic Interventions: A Systematic Review Protocol

Prakoeswa,

Asaduddin,

Pramuningtyas

et al. 2023

Preprint

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Leprosy is resulted from chronic infection by Mycobacterium leprae. Leprosy affects the skin, peripheral nerves, and upper respiratory tract. Leprosy is a global health concern and Indonesia has the highest prevalence of leprosy in the world. The disease is characterized by a cytokine response, which is associated with increased inflammatory activity in both limited and multibacillary forms. Therefore, in vitro and in vivo studies are necessary to understand the disease and develop more effective treatments. This systematic search was conducted in several international databases including Scopus, PubMed, ScienceDirect, and Epistemonikos. A search strategy that combined keywords based on Medical Subject Headings (MeSH) and free text, including mice, leprosis, bacterial examination and histopathology. The search was performed using a systematic search strategy. We performed data extraction independently using predefined sheets that included the following information: first author name, year of publication, sample size and characteristics, duration of follow up, exposure method, intervention grouping, and outcomes (bacterial examination, histopathological evaluation, and other inflammatory markers). The results of the risk of bias assessment were displayed in the form of traffic-light plot and summary plot graphs, illustrating the results of a low, high, or unclear risk of biased assessment. The data was analyzed qualitatively.

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Susceptibility and resistance in leprosy: Studies in the mouse model

Abstract: This article is part of a series of reviews covering Immunity to Mycobacteria appearing in Volume 301 of Immunological Reviews.

Cited by 20 publications

References 120 publications

Pyrethroid Resistance Situation across Different Eco-Epidemiological Settings in Cameroon

Pyrethroid Resistance Situation across Different Eco-Epidemiological Settings in Cameroon

Qua vadis leprosy?

Utilization of Mice as Hansen Disease Models for Comprehensive Analysis of Pathogenesis, Immunological Responses, and Therapeutic Interventions: A Systematic Review Protocol

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