Susceptibility-Based Neuroimaging: Standard Methods, Clinical Applications, and Future Directions

Abstract

The evaluation of neuropathologies using MRI methods that leverage tissue susceptibility have become standard practice, especially to detect blood products or mineralization. Additionally, emerging MRI techniques have the ability to provide new information based on tissue susceptibility properties in a robust and quantitative manner. This paper discusses these advanced susceptibility imaging techniques and their clinical applications.

MEDI+0: Morphology enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference for quantitative susceptibility mapping

“…MEDI+0 may directly improve the delineation of deep gray nuclei, including the subthalamic nucleus, which is an important surgical target of deep brain stimulation (44). The zero reference in MEDI+0 will be very useful for longitudinal studies as in time-course investigation of multiple sclerosis lesions (23), for differentiation of diamagnetic materials from paramagnetic ones (45,46), for estimating the oxygenation level of venous blood (7,47,48) and tissue (6), for measuring biodistributions in magnetically labeled drug delivery (49,50), and for monitoring iron level during iron chelating therapy (51). As QSM has already been used in clinical applications, it is important to examine the extent to which MEDI+0 alters the relative contrast between tissues outside the CSF.…”

Multiparametric MRI dataset for susceptibility-based radiomic feature extraction and analysis

“…In fact, numerous neurological conditions in both adults and children have demonstrated abnormal accumulations of blood-related substances or mineral deposits. Thus, Susceptibility-Based Imaging (SBI) 3 has found application in clinical settings. While traditional SBI methods, like Susceptibility Weighted Imaging (SWI) 4 , 5 , offer valuable insights, they come with certain limitations compared to QSM 2 , which provides quantitative measurements, enables comparisons within and between different groups, and facilitates the discrimination between diamagnetic and paramagnetic substances.…”