Susceptibility Genetics in the Etiopathogenesis of Alzheimer's Disease: Role for Potential Confounding Factors

Harrington, Charles R.; Roth, Martin

doi:10.1017/s1041610297004390

Cited by 3 publications

(1 citation statement)

References 68 publications

(59 reference statements)

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“…While mortality crossover is a well-accepted concept reflecting survivor effects (or simply misreporting) (24), the concept of morbidity crossover is less well developed. A crossover between what has been referred to as "advantaged" and "disadvantaged" groups allows speculation that further detailing of the dynamics of these deficits may provide clues to the delineation of late life expressions of genetic susceptibility factors (41) and/or environmental insults that occurred at a much earlier point in time (42)(43)(44). While extraneous and currently unknown factors may modify some genetically predetermined maximum life span, it might well be that we can establish personal biologic age based upon functional and cognitive capacities separate from chronologic age.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Cognitive Aging: Distinguishing Functional Age and Disease from Chronologic Age in a Population

Graham

Mitnitski

Mogilner³

et al. 1999

American Journal of Epidemiology

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This paper introduces a methodological approach to the dynamics of cognitively normal (i.e., successful) aging compared with aging accompanied by different types of cognitive impairment and dementia. Using secondary analysis of a national representative database (Canadian Study of Health and Aging, 1991-1992), the authors show that the occurrence of an adverse event (symptom, sign, or disease), or the accumulation of a number of events, may be modeled as a logistic function of chronologic age in a population. In the cognitively normal, a linear relation between the logarithm of the odds of events and chronologic age was present for the majority of symptoms and signs. This regression represents the accumulation of each sign in a cognitively successful, aging population. The authors then estimated which ages for this cognitively unimpaired group correspond to the odds of the occurrence of symptoms found for a cognitively impaired population at any given chronologic age. This may be regarded as functional age, based upon the accumulation of a particular functional deficit in the impaired population, analogous to the concept of frailty. The dynamics of aging are a complex process of accumulation of deficits (morbidity), whereby decline from some previously healthy level of synergistically associated symptoms and signs results in distinct patterns of disease and staging. The modeling of these dynamics takes us a step further toward the definition and refinement of disease and normal aging.

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Section: Discussionmentioning

confidence: 99%

Dynamics of Cognitive Aging: Distinguishing Functional Age and Disease from Chronologic Age in a Population

Graham

Mitnitski

Mogilner³

et al. 1999

American Journal of Epidemiology

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The Aetiology of Alzheimer’s Disease: Diverse Routes into a Common Tau Pathway

Harrington

2001

Aluminium and Alzheimer's Disease

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Risk Factors in Psychosis Secondary to Traumatic Brain Injury

Fujii

Ahmed²

2001

JNP

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Psychosis is a rare but devastating sequela of traumatic brain injury (TBI). This study examined risk factors for developing a psychosis secondary to TBI (PSTBI). Demographics of 25 inpatients with PSTBI were statistically analyzed for risk factors. Data from the PSTBI group were also compared with data from a control group of TBI patients without psychosis. Results indicate the PSTBI group was more likely to have had a previous congenital neurological disorder or to have sustained a head injury prior to adolescence. The PSTBI also had a higher proportion of males. Discussion focuses on potential models for developing PSTBI.

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Susceptibility Genetics in the Etiopathogenesis of Alzheimer's Disease: Role for Potential Confounding Factors

Abstract: An association between the apolipoprotein E E4 allele and AD was first demonstrated by Strittmatterand colleagues (1993). 229https://www.cambridge.org/core/terms. https://doi

Cited by 3 publications

References 68 publications

Dynamics of Cognitive Aging: Distinguishing Functional Age and Disease from Chronologic Age in a Population

Dynamics of Cognitive Aging: Distinguishing Functional Age and Disease from Chronologic Age in a Population

The Aetiology of Alzheimer’s Disease: Diverse Routes into a Common Tau Pathway

Risk Factors in Psychosis Secondary to Traumatic Brain Injury

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