Susceptibility of Argentinean Biomphalaria tenagophila and Biomphalaria straminea to infection by Schistosoma mansoni and the possibility of geographic expansion of mansoni schistosomiasis

Simões, Luciana Franceschi; Camargo, Eliana Anunciato Franco de; Bastos, Leticia Duart; Neves, Maria Francisca; Carvalho, José Ferreira de; Magalhães, Luiz Augusto; Zanotti-Magalhães, Eliana Maria

doi:10.1590/0037-8682-0131-2013

Cited by 10 publications

(12 citation statements)

References 27 publications

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“…This observation might suggest that these populations are resistant to the penetration and development of S. mansoni as a consequence of genetic predisposition of these snails to destroy the parasite as a foreign entity. A similar result was obtained by Simões et al [6] in populations of Biomphalaria taenagophila and B. straminea , intermediate hosts of S. mansoni in Brazil. However, the Petponoun population exhibited a relatively high susceptibility rate (21.9%), quite similar to that of other B. pfeifferi [10], B. glabrata (the main host of intestinal schistosomiasis in Brazil) [25] and B. taenagophila [26] populations.…”

Section: Compatibilitysupporting

confidence: 89%

“…Despite these control measures, the current epidemiological situation reveals the persistence of schistosomiasis in some foci, and the emergence of new foci of the disease [3–5]. The establishment of new foci could be explained by the migration of parasitized individuals to disease free sites where sanitation is inadequate and intermediate hosts present [6]. To efficiently interrupt schistosomiasis transmission, the WHO recommends a synergy of actions, among which the fight against intermediate hosts holds a prominent place [7].…”

Section: Introductionmentioning

confidence: 99%

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Biomphalaria camerunensis as a viable alternative intermediate host for Schistosoma mansoni in southern Cameroon

et al. 2018

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BackgroundIntestinal schistosomiasis due to Schistosoma mansoni was mapped in Cameroon in the 1990s and preventive chemotherapy launched since 2005. A situation analysis conducted in 2011 revealed an increase in schistosomiasis transmission, especially in the equatorial part of the country, despite the fact that Biomphalaria pfeifferi, the main intermediate host of this parasite, is now scarce in many foci. Biomphalaria camerunensis, restricted to the equatorial part of the country, is considered as a less suitable host for S. mansoni due to it resistance to the parasite, although exhibiting a better survival than B. pfeifferi. In a context where human migration is quite frequent as a consequence of terrorism, war in neighboring countries, as well as development of hydraulic projects, it seems appropriate to evaluate the current epidemiological role of B. camerunensis to estimate the risk of extension of S. mansoni distribution in Cameroon. To do this, the susceptibility of three B. pfeifferi and five B. camerunensis populations to a strain of S. mansoni was assessed. Juvenile snails (G1) of each population were infected with S. mansoni miracidia, and prepatent period, infection and survival rates of infected snails, as well as cercarial production were recorded and compared between snail species and populations.ResultsCompatibility tests were performed on a total of 827 snails: 344 B. pfeifferi and 483 B. camerunensis. Infection rates were quite heterogeneous, higher in B. pfeifferi (61.5%) as compared to B. camerunensis (7.8%) (Chi-square test: χ2 = 258.88, df = 1, P < 0.0001). All the three B. pfeifferi-infected populations were susceptible to S. mansoni. However, among the five B. camerunensis populations tested, four were susceptible to S. mansoni, with 21.9% as the highest infection rate. The prepatent period was, on average, shorter in B. pfeifferi than in B. camerunensis (P < 0.0001), but the cercarial production was significantly higher in B. camerunensis as compared to B. pfeifferi (P < 0.001).ConclusionThese findings indicate that B. camerunensis populations might substantially contribute to S. mansoni transmission and dissemination in Cameroon, their low susceptibility being compensated by their high cercariae production. More attention and surveillance towards this species are required to achieve intestinal schistosomiasis elimination in Cameroon.Electronic supplementary materialThe online version of this article (10.1186/s13071-018-2763-2) contains supplementary material, which is available to authorized users.

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Section: Compatibilitysupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Biomphalaria camerunensis as a viable alternative intermediate host for Schistosoma mansoni in southern Cameroon

et al. 2018

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“…Each species of Biomphalaria that is a natural or potential host for S. mansoni consists in populations that exhibit varying degrees of susceptibility to different local strains of the parasite (Paraense & Côrrea, 1973; Paraense & Côrrea, 1978; Paraense & Côrrea, 1985; Coelho et al, 2004; Simões et al, 2013; Marques et al, 2014). The susceptibility to S. mansoni has been shown to be heritable and linked to the gene pool of the IHs, each of which—according to its capability for reproduction through cross- or self-fertilization—produces progeny with differing degrees of parasitotrophic susceptibility (Newton, 1953; Richards & Merritt Jr, 1972; Richards, 1973; Richards, 1975; Coelho et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…These results are highly relevant since Paraense & Côrrea (1973) demonstrated experimentally that populations of B. peregrina from Lapa of Paraná (in Brazil), and Chillogallo (in Ecuador) are markedly susceptible to infection with the BH (Belo-Horizonte) and SJ (San-Jose) strains of S. mansoni , though these B. peregrina strains have not yet been found to be infected in the wild. Although the susceptibility to different strains of S. mansoni of populations of B. peregrina that inhabit subtropical or temperate areas have still not been evaluated, other Biomphalaria species such as B. tenagophila and B. straminea in the northeast of Argentina have indeed been found to serve experimentally as IHs of several strains of S. mansoni (Borda & Rea, 1997; Simões et al, 2013). In this context, new studies on the susceptibility and genetic variation of diverse variants and morphotypes of B. peregrina are needed involving populations that contain the haplotypes identified here as subtropical and temperate.…”

Section: Discussionmentioning

confidence: 99%

The South-American distribution and southernmost record ofBiomphalaria peregrina—a potential intermediate host of schistosomiasis

Rumi

Vogler

Beltramino

2017

PeerJ

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Schistosomiasis remains a major parasitic disease, endemic in large parts of South America. Five neotropical species of Biomphalaria have been found to act as intermediate hosts of Schistosoma mansoni in natural populations, while others have been shown to be susceptible in experimental infections, although not found infected in the field. Among these potential intermediate hosts, Biomphalaria peregrina represents the most widespread species in South America, with confirmed occurrence records from Venezuela to northern Patagonia. In this study, we report the southernmost record for the species at the Pinturas River, in southern Patagonia, which finding implies a southward reassessment of the limit for the known species of this genus. The identities of the individuals from this population were confirmed through morphological examination, and by means of two mitochondrial genes, cytochrome oxidase subunit I (COI) and 16S-rRNA. With both markers, phylogenetic analyses were conducted in order to compare the genetic background of individuals from the Pinturas River with previously genetically characterized strains of B. peregrina from various South-American locations. In addition, we produced a potential distribution model of B. peregrina in South America and identified the environmental variables that best predict that distribution. The model was estimated through a maximum entropy algorithm and run with occurrence points obtained from several sources, including the scientific literature and international databases, along with climatic and hydrographic variables. Different phylogenetic analyses with either the COI or 16S-rRNA sequences did not conflict, but rather gave very similar topological organizations. Two major groups were identified, with sequences from the Pinturas River grouping together with haplotypes from subtropical and temperate regions. The model developed had a satisfactory performance for the study area. We observed that the areas with higher habitat suitability were found to be mainly linked to subtropical and temperate regions of South America between 15° and 45° south latitude, with different moderate- and low-suitability areas outside this range. We also identified the coldest temperatures as the main predictors of the potential distribution of this snail. Susceptibility surveys would be required to evaluate if southern populations of B. peregrina still retain their potential as intermediate hosts of S. mansoni.

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“…This highlights the importance of the heredity of susceptibility among snails and the maintenance of foci of the disease. Other studies have reported that a similar population of snails may respond differently when exposed to different strains of S. mansoni, and that some of these strains exhibit pre-adapted phenotypes that can affect the degree of parasitism, thereby enabling the potential expansion of the schistosomiasis to new locations, where snail populations are found (Teodoro et al, 2011;Simões et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Host-parasite relationship between Biomphalaria amazonica (Paraense, 1966) and Schistosoma mansoni (Sambon, 1907)

et al. 2016

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Biomphalaria amazonica is a planorbid species considered a potential host of Schistosoma mansoni. It is widely distributed in the Neotropical zone, particularly in the North and Centre-West of Brazil and in the North of Bolivia. The aim of the present study was to determine the host-parasite relationship between B. amazonica and S. mansoni (BH and SJ strains). Specimens of B. amazonica and their snail-conditioned water were examined in terms of their ability to attract miracidia. The infectivity of the mollusks was determined by exposing them to 20 miracidia of both strains. Sporocyst development and amebocyte reactions were studied after each mollusk specimen was exposed to 100 miracidia. Although no cercariae were eliminated, specimens of B. amazonica proved capable of attracting 77% of the miracidia they were exposed to. Viable sporocysts with no amebocyte reaction were found 96 hours after the exposure to miracidia. These results indicate the susceptibility of B. amazonica to the BH and SJ strains of S. mansoni, and therefore demonstrate the importance of this planorbid species as a potential vector of the trematode in the areas where it occurs.Keywords: schistosomiasis, susceptibility, BH strain, SJ strain. Relação parasito-hospedeiro entre

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Susceptibility of Argentinean Biomphalaria tenagophila and Biomphalaria straminea to infection by Schistosoma mansoni and the possibility of geographic expansion of mansoni schistosomiasis

Abstract: These results demonstrate that species from Argentina have the potential to be natural hosts of S. mansoni and that the appearance of foci of mansoni schistosomiasis in Argentina is possible.

Cited by 10 publications

References 27 publications

Biomphalaria camerunensis as a viable alternative intermediate host for Schistosoma mansoni in southern Cameroon

Biomphalaria camerunensis as a viable alternative intermediate host for Schistosoma mansoni in southern Cameroon

The South-American distribution and southernmost record ofBiomphalaria peregrina—a potential intermediate host of schistosomiasis

Host-parasite relationship between Biomphalaria amazonica (Paraense, 1966) and Schistosoma mansoni (Sambon, 1907)

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