Susceptibility of bacteria to serum lysis or phagocytosis following growth in subinhibitory levels of lincosaminide or spectinomycin related antibiotics.

Cialdella, J. I.; Vavra, James J.; Marshall, Vincent P.

doi:10.7164/antibiotics.39.978

Cited by 11 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, the mechanism of pirlimycin action is that it increases the susceptibility of the pathogen to phagocytosis by polymorphonuclear leukocytes after exposure to sub‐inhibitory concentrations (Cialdella et al . ). Whittem () reported that intramammary infusion induces a rapid increase in the MIC of microorganisms isolated from the mammary glands of dairy heifers.…”

Section: Resultsmentioning

confidence: 97%

Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan

Kawai

Higuchi

Iwano

et al. 2013

Animal Science Journal

View full text Add to dashboard Cite

Mycoplasma spp. are highly contagious pathogens and intramammary Mycoplasma infection is a serious issue for the dairy industry. As there is no effective vaccine for Mycoplasma infection, control depends on good husbandry and chemo-antibiotic therapy. In this study, antimicrobial susceptibility of Mycoplasma strains recently isolated from cases of bovine mastitis in Japan was evaluated by minimum inhibitory concentration (MIC). All Mycoplasma bovis strains were sensitive to pirlimycin, danofloxacin and enrofloxacin, but not kanamycin, oxytetracycline, tilmicosin or tylosin. M. californicum and M. bovigenitalium strains were sensitive to pirlimycin, danofloxacin, enrofloxacin, oxytetracycline, tilmicosin and tylosin, but not to kanamycin. This is the first report to describe the MIC of major antimicrobial agents for Mycoplasma species isolated from bovine mastitis in Japan.

show abstract

Section: Resultsmentioning

confidence: 97%

Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan

Kawai

Higuchi

Iwano

et al. 2013

Animal Science Journal

View full text Add to dashboard Cite

show abstract

“…It has activity against some pathogens which cause bovine mastitis including Staphylococcus aureus ( Owens et al ., 1993a ; Watts & Salmon, 1997), Staphylococcus spp., many streptococci ( Thornsberry et al ., 1993 ) and some entero‐cocci ( Thornsberry et al ., 1993 ; Watts et al ., 1995 ). Pirlimycin exhibits a post antibiotic effect in vitro against Staphylococcus aureus isolated from bovine mastitis ( Owens et al ., 1993b ) and causes increased susceptibility of the pathogen to phagocytosis by polymorphonuclear leukocytes after exposure to subinhibitory concentrations of the antibiotic ( Cialdella et al ., 1986 ). Many species of anaerobic bacterial pathogens are extremely sensitive to pirlimycin ( Qadri et al ., 1983 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and milk discard times of pirlimycin after intramammary infusion: a population approach

Whittem

1999

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

A population pharmacokinetic approach was used to analyse milk concentration data to determine whether milk discard times and the clearance of intramammary infusions of pirlimycin could be adequately predicted by readily available demographic variables. Milk samples were collected at 12 hourly milking intervals after dosing with pirlimycin during product development from both normal cows (primary data) and cows with naturally occurring mastitis (validation data) and pirlimycin concentration was determined by microbial inhibition assay. The data were analysed by the conditional estimation/ maximum likelihood population approach within the computer program PPharm and fitted a two compartment open model. Bayesian estimates of individual parameters allowed solutions for each cow, predicting the time after last dosing by which milk concentration reached the target safe concentration. From this population of times, the 95% confidence interval of the 99th percentile was defined as the milk discard time. After elimination of one very low producing outlier, the calculated discard time agreed with the label recommendation of 36 h (3 milkings, USA) after the last dose. Milk pirlimycin clearance was strongly and positively correlated to the logarithm of the kilograms of milk produced in 24 h at time of dosing (r2=0.939). Agreement was strong at most time points between predicted and measured pirlimycin concentrations in milk from cows with mastitis. This alternative method for determining milk discard times was compared to existing recommendations.

show abstract

“…Additionally, lincomycin induced a nonsignificant increase in phagocytic activity and index (Fateeva 1983) and (Faden et al 1985). Furthermore, lincosamides have dramatically increased phagocytic activity (Cialdella et al 1986) as well as achieves high intracellular levels of phagocytic cells (Alikhani & Salehifar 2012). Our data coordinated with the findings showing that bacitracin induced a non-significant elevation in phagocytic activity and phagocytic index (Adel 2018).…”

Section: Discussionmentioning

confidence: 99%

Comparative studies on the effects of lincomycin and bacitracin on hematobiochemical and immunological parameters in broiler chickens

Elkomy

Farag

Elgharbawy

et al. 2019

IJPT

View full text Add to dashboard Cite

A total of 100 one-day-old healthy broiler chicks were used to study the effects of lincomycin and bacitracin on some hematobiochemical and immunological parameters. Chicks were divided into four equal groups, 25 each. The first group was kept as control; the 2nd group was received 0.5 g of lincomycin per liter; the 3rd group was received 100 mg bacitracin per liter and the 4th group was administered both lincomycin and bacitracin, each at the above-mentioned dose. Drugs were given in drinking water for 5 successive days from 20th to 25th day of age. Bodyweight was recorded at the beginning of the experiment and at 1st-day post administration where body performance was recorded. One day post administration, blood samples were collected for estimation of hematobiochemical and immunological alterations. The obtained results revealed that broiler chicks administered lincomycin or bacitracin or both revealed a marked increase in bodyweight, weight gain, phagocytic activity, phagocytic index, erythrocytic count, hemoglobin level, packed cell volume, total leukocytic count, serum total protein, albumin, total globulin, α, β and γ globulin. Furthermore, a significant elevation in malondialdehyde associated with a marked reduction in albumin-globulin ratio, serum total lipid, cholesterol and triglyceride and a significant decrease in catalase and superoxide dismutase, were recorded, compared with the control group. In conclusion, lincomycin and bacitracin either alone or in combination have positive impacts on growth performance, immunological and hematobiochemical parameters of broiler chickens. So, it is recommended to use both drugs as growth promoters in broiler chickens.

show abstract

Susceptibility of bacteria to serum lysis or phagocytosis following growth in subinhibitory levels of lincosaminide or spectinomycin related antibiotics.

Cited by 11 publications

References 2 publications

Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan

Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan

Pharmacokinetics and milk discard times of pirlimycin after intramammary infusion: a population approach

Comparative studies on the effects of lincomycin and bacitracin on hematobiochemical and immunological parameters in broiler chickens

Contact Info

Product

Resources

About