Susceptibility of individuals with lung dysfunction to systemic inflammation associated with ambient fine particle exposure: A panel study in Beijing

Chen, Xi; Que, Chengli; Yao, Yuan; Zhang, Hanxiyue; Li, Xiaoying; Lu, Xiaogang; Wu, Chen; Xiong, Hu; Wu, Yusheng; Wang, Teng; Zhang, Lina; Zheng, Mei; Qiu, Xinghua; Zhu, Tong

doi:10.1016/j.scitotenv.2021.147760

Cited by 12 publications

(14 citation statements)

References 38 publications

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“…Serum concentrations of IL-1β, IL-8, MCP-1, MIP-1α, MIP-1β, and TNF-α were measured using an immunological method employing Milliplex technology (Merck & Co. Inc., Kenilworth, NJ, USA) following the manufacturer’s instructions (HCYTOMAG-60K kit) [ 25 , 56 ]. Briefly, 25 µL serum and 25 µL bead suspension were mixed in the wells of 96-well microplates and incubated for 18 h at 4 °C in the dark.…”

Section: Methodsmentioning

confidence: 99%

“…The associations between serum TxB2 concentrations and the average concentrations of air pollutants were evaluated using linear mixed-effects (LMEs) models with participant-specific random intercepts, which accounts for the correlations that arise from intraindividual repeated observations. The exposure time windows were within 14 days preceding the clinical visits, as suggested by similar studies on COPD [ 24 , 25 ]. The models included age, sex, the BMI, smoking status, educational level, income, and the day of the week.…”

Section: Methodsmentioning

confidence: 99%

“…However, few studies on COPD patients have appeared. We and other groups have reported that short-term exposure to PM is associated with biomarkers of lipid peroxidation and systemic inflammation in COPD patients [12,[23][24][25][26], which might trigger platelet activation and thrombosis [27,28]. Thus, we hypothesized that short-term exposure to PM would be associated with pro-thrombotic changes in patients with COPD.…”

Section: Introductionmentioning

confidence: 94%

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Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation

Wang

Chen

et al. 2022

Part Fibre Toxicol

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Background Exposure to particulate matter air pollution is associated with an increased risk of cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are not yet understood. Enhanced platelet and pro-thrombotic activity in COPD patients may explain their increased cardiovascular risk. We aim to explore whether short-term exposure to ambient particulate matter is associated with pro-thrombotic changes in adults with and without COPD, and investigate the underlying biological mechanisms in a longitudinal panel study. Serum concentration of thromboxane (Tx)B2 was measured to reflect platelet and pro-thrombotic activity. Lipoxygenase-mediated lipid peroxidation products (hydroxyeicosatetraenoic acids [HETEs]) and inflammatory biomarkers (interleukins [ILs], monocyte chemoattractant protein-1 [MCP-1], tumour necrosis factor alpha [TNF-α], and macrophage inflammatory proteins [MIPs]) were measured as potential mediating determinants of particle-associated pro-thrombotic changes. Results 53 COPD and 82 non-COPD individuals were followed-up on a maximum of four visits conducted from August 2016 to September 2017 in Beijing, China. Compared to non-COPD individuals, the association between exposure to ambient ultrafine particles (UFPs) during the 3–8 days preceding clinical visits and the TxB2 serum concentration was significantly stronger in COPD patients. For example, a 103/cm3 increase in the 6-day average UFP level was associated with a 25.4% increase in the TxB2 level in the COPD group but only an 11.2% increase in the non-COPD group. The association in the COPD group remained robust after adjustment for the levels of fine particulate matter and gaseous pollutants. Compared to the non-COPD group, the COPD group also showed greater increases in the serum concentrations of 12-HETE (16.6% vs. 6.5%) and 15-HETE (9.3% vs. 4.5%) per 103/cm3 increase in the 6-day UFP average. The two lipid peroxidation products mediated 35% and 33% of the UFP-associated increase in the TxB2 level of COPD patients. UFP exposure was also associated with the increased levels of IL-8, MCP-1, MIP-1α, MIP-1β, TNF-α, and IL-1β in COPD patients, but these inflammatory biomarkers did not mediate the TxB2 increase. Conclusions Short-term exposure to ambient UFPs was associated with a greater pro-thrombotic change among patients with COPD, at least partially driven by lipoxygenase-mediated pathways following exposure. Trial registrationChiCTR1900023692. Date of registration June 7, 2019, i.e. retrospectively registered.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation

Wang

Chen

et al. 2022

Part Fibre Toxicol

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“…Especially the ultrafine particles ( D P < 100 nm) formed by the modern low mass emission engines are more harmful to the human body and environment. 7 − 9 Therefore, strict regulations have been enacted all over the world to limit the pollutant emissions from diesel engines, 10 and research work on low-emission technologies for diesel engines is in full swing. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

“…NO x in the atmosphere can be oxidized to HNO 3 and then deposited as acid rain, which will adversely affect drinking water, soil, and biodiversity. , The particles produced by diesel engines can easily penetrate into the respiratory tract and affect human health. Especially the ultrafine particles ( D P < 100 nm) formed by the modern low mass emission engines are more harmful to the human body and environment. − Therefore, strict regulations have been enacted all over the world to limit the pollutant emissions from diesel engines, and research work on low-emission technologies for diesel engines is in full swing. , …”

Section: Introductionmentioning

confidence: 99%

Effects of Intake Components and Stratification on the Particle and Gaseous Emissions of a Diesel Engine

et al. 2022

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It is of great significance to improve the performance of diesel engines by adjusting the intake components and their distribution. In this work, various proportions of exhaust gas recirculation (EGR) gas and oxygen (O 2 ) have been introduced to the intake charge of a diesel engine and the effects of different intake components and stratification conditions on pollutant emissions, especially for particles, have been explored. The results show that the introduction of O 2 into the intake charge is beneficial to alleviate the deterioration of particles and hydrocarbon (HC) emissions caused by high EGR rates. Compared with the pure air intake condition, the introduction of moderate O 2 at high EGR rate conditions can simultaneously reduce nitrogen oxides (NO x ) and particles, when the intake oxygen content (IOC) is 0.2 and the EGR rate is 20%, the NO x and particles are reduced by 45.66% and 66.49%, respectively. It is worth noting that different intake components have a significant impact on the particle size distribution (PSD) of diesel engines. In addition, the in-cylinder O 2 concentration distribution formed by the stratified intake is advantageous for further improving the combined effect of NO x , particles and HC emissions relative to the homogeneous intake. At a condition of 0.2 IOC and 20% EGR rate, the NO x , particles, and HC emissions are about 8.8%, 14.3%, and 26% lower than that of intake components nonstratification, respectively.

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Risk factors in air pollution exposome contributing to higher levels of TNFα in COPD patients

Chen

Luan

Yao

et al. 2022

Environment International

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Susceptibility of individuals with lung dysfunction to systemic inflammation associated with ambient fine particle exposure: A panel study in Beijing

Cited by 12 publications

References 38 publications

Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation

Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation

Effects of Intake Components and Stratification on the Particle and Gaseous Emissions of a Diesel Engine

Risk factors in air pollution exposome contributing to higher levels of TNFα in COPD patients

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