Susceptibility of neisseria gonorrhoeae to gentamicin, chloramphenicol and other antibiotics in Manaus, Amazon, Brazil

Abstract

We notify the antimicrobial tests of 83 N. gonorrhoeae isolates. The results showed that it is not viable to use penicillin and tetracycline to treat the disease. The resistance to quinolones has not precluded therapy yet. All gonococci were sensitive to ceftriaxone, and the low level of resistance to gentamicin and chloramphenicol may suggest their usage as a future therapeutic option. Keywords: Neisseria gonorrhoeae; antimicrobial; gentamicins; chloramphenicol; resistance. RESUMOReportamos os resultados de testes de suscetibilidade realizados com 83 isolados de N. gonorrhoeae. Os resultados demonstram que não é viável a utilização de penicilina e tetraciclina para o tratamento da doença. A frequência de resistência às quinolonas detectada neste corte ainda possibilita sua utilização na terapêutica. Todos os gonococos testados foram sensíveis à ceftriaxona. O reduzido nível de resistência à gentamicina e ao cloranfenicol demonstra que esses antibióticos podem ser utilizados como opção terapêutica futura.

Gentamicin Susceptibility among a Sample of Multidrug-Resistant Neisseria gonorrhoeae Isolates in India

“…Our findings are more similar to those of studies from Mongolia and Brazil, where 100% of the isolates were susceptible to gentamicin (13,17). Observations of the European study (14) were similar to those from Malawi (9) and Canada (16), where the majority of isolates were less susceptible.…”

“…Some of these studies were on a limited number of isolates (13,17). To the best of our knowledge, no study has analyzed the in vitro susceptibility of gentamicin against MDR strains.…”

“…Gentamicin has been used for the past 2 decades in the management of gonorrhea in Malawi (8, 9). Gentamicin has been considered an option for the treatment of infections due to the MDR and XDR strains and for future treatment of gonorrhea particularly in dual therapy in other geographic regions (10-12).Earlier studies focused on the in vitro susceptibility of N. gonorrhoeae to gentamicin (8,(13)(14)(15)(16)(17). Some of these studies were on a limited number of isolates (13,17).…”

“…Earlier studies focused on the in vitro susceptibility of N. gonorrhoeae to gentamicin (8,(13)(14)(15)(16)(17). Some of these studies were on a limited number of isolates (13,17).…”