Susceptibility of Staphylococcus aureus to porphyrin-silver nanoparticle mediated photodynamic antimicrobial chemotherapy

Shabangu, Samuel M.; Babu, Balaji; Soy, Rodah C.; Oyim, James; Amuhaya, Edith; Nyokong, Tebello

doi:10.1016/j.jlumin.2020.117158

Cited by 18 publications

(10 citation statements)

References 40 publications

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“…Previous studies have shown that some bacteria show resistance against PDI 31,49,56 . The increase in bacterial inactivation of MRSA and MDR E. coli by PpIX-AgNPs following light irradiation is consistent with the patterns recorded in literature 19,[22][23][24][25]37 . Also, other studies have reported complete elimination of MRSA and E. coli using AgNPs only; however, MIC are at least 5 µg/mL depending on the physiochemical properties of the examined AgNPs 25, 54, 57 .…”

Section: Bacteria Inactivationsupporting

confidence: 91%

“…Investigation of the release profile of Ag + from AgNPs, PpIX-AgNPs and PEI-PpIX-AgNPs Previous reports have described the combination of PSs with AgNPs. 19,[22][23][24][25]37 Most of these studies are limited to demonstrating the increased antimicrobial effect of PS-AgNPs in terms of the enhanced PS photochemical properties. As far as we know, only one study has investigated the oxidative effect of PSs on the release of Ag + after light irradiation.…”

Section: Paper Materials Advancesmentioning

confidence: 99%

“…Recent studies have shown that the PS-AgNP combination have synergistic antimicrobial effect. These studies demonstrated that the synergistic antimicrobial effect of PS-AgNP conjugates in bacteria (non-resistant) is concentration dependent and contributed by the oxidative stress due to enhanced ROS production 19,[22][23][24][25] . However, there is a lack of understanding on the impact of the light-mediated release of Ag + in these systems, which is also a critical parameter that contributes to the antibacterial synergy in PSs and AgNPs conjugates.…”

Section: Introductionmentioning

confidence: 96%

“…These studies demonstrated that the synergistic antimicrobial effect of PS-AgNP conjugates in bacteria (non-resistant) is concentration dependent and contributed by the oxidative stress due to enhanced ROS production. 19,[22][23][24][25] However, there is a lack of understanding of the impact of the light-mediated release of Ag + in these systems, which is also a critical parameter that contributes to the antibacterial synergy in PSs and AgNPs conjugates. Herein, we report an in-depth study to understand the role of PSmediated ROS generation in Ag + release and its antimicrobial effect against antibiotic resistant bacteria (ARB).…”

Section: Introductionmentioning

confidence: 99%

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Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles

et al. 2022

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Section: Bacteria Inactivationsupporting

confidence: 91%

Section: Paper Materials Advancesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles

et al. 2022

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“…The conjugation of porphyrins to nanoparticles has been explored. The conjugates have been found to exhibit enhanced antimicrobial properties and this is attributed to their biocompatibility and synergistic properties for PACT ( Shabangu et al, 2020 ). By taking advantage of the small size of the porphyrins and porphyrin-nanoparticle conjugates, the photosensitizers can attach to the bacterial cell wall through a self-assembly process, resulting in cell death.…”

Section: Advancement Of Porphyrin-based Photosensitizers For Targetedmentioning

confidence: 99%

Photodynamic Antimicrobial Chemotherapy: Advancements in Porphyrin-Based Photosensitize Development

2021

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The reduction of available drugs with effectiveness against microbes is worsening with the current global crisis of antimicrobial resistance. This calls for innovative strategies for combating antimicrobial resistance. Photodynamic Antimicrobial Chemotherapy (PACT) is a relatively new method that utilizes the combined action of light, oxygen, and a photosensitizer to bring about the destruction of microorganisms. This technique has been found to be effective against a wide spectrum of microorganisms, including bacteria, viruses, and fungi. Of greater interest is their ability to destroy resistant strains of microorganisms and in effect help in combating the emergence of antimicrobial resistance. This manuscript reviews porphyrins and porphyrin-type photosensitizers that have been studied in the recent past with a focus on their structure-activity relationship.

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The Photodynamic Antibacterial Activity Properties of a Series of Indium(III) Porphyrins and their Gold and Silver Nanoparticle Conjugates

Soy,

Mafukidze,

Mack

et al. 2024

Eur J Inorg Chem

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In(III) tetraarylporphyrin complexes with 4‐thiomethylphenyl (1‐InPor), thien‐3‐yl (2‐InPor), thien‐2‐yl (3‐InPor) and 5‐bromothien‐2‐yl (4‐InPor) meso‐aryl rings have been synthesized and characterized. The complexes have been conjugated to gold and silver nanoparticles (AuNPs and AgNPs). The photodynamic antimicrobial chemotherapy (PACT) activities of 1‐4‐InPor and their AuNP and AgNP conjugates have been investigated against both planktonic bacteria and biofilms of Gram‐(+) S. aureus and Gram‐(−) E. coli. 2.5 µg.mL−1 solutions of 1‐4‐InPor exhibited favorable PACT activities against planktonic S. aureus with high Log10 reduction values in the 4.28−7.69 range upon 75 min photoirradiation with a Thorlabs M625L3 LED (240 mW.cm−2) mounted onto the illumination chamber of a Modulight 7710 medical laser system to provide a dose at the well‐plate of 86 mJ.cm−2.min−1. In contrast, low values in the 1.4−1.9 range were obtained against E. coli with 10 µg.mL−1 solutions. 1‐4‐InPor exhibited relatively low PACT activity against the biofilm cells of S. aureus and E. coli. Conjugation of 1‐4‐InPor to AgNPs and AuNPs significantly enhanced the PACT activities. This is demonstrated by the complete eradication of planktonic S. aureus at shorter irradiation times with high Log10 values > 7.69 and moderate Log10 values > 2 against planktonic E. coli for the meso‐thienylporphyrin conjugates.

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Susceptibility of Staphylococcus aureus to porphyrin-silver nanoparticle mediated photodynamic antimicrobial chemotherapy

Cited by 18 publications

References 40 publications

Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles

Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles

Photodynamic Antimicrobial Chemotherapy: Advancements in Porphyrin-Based Photosensitize Development

The Photodynamic Antibacterial Activity Properties of a Series of Indium(III) Porphyrins and their Gold and Silver Nanoparticle Conjugates

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