Susceptibility of Trypanosoma evansi to propolis extract in vitro and in experimentally infected rats

Gressler, Lucas T.; Silva, Aleksandro S. Da; Machado, Gustavo; Rosa, Luís Henrique Telles da; Dorneles, Fellipe de Souza; Gressler, Letícia Trevisan; Oliveira, Maurício Schneider; Zanette, Régis A.; Vargas, Agueda C.P. de; Monteiro, Sílvia González

doi:10.1016/j.rvsc.2012.02.007

Cited by 30 publications

(20 citation statements)

References 26 publications

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“…in trypanosomosis control has the ability to normalize blood parameters (hematocrit, total hemoglobin and erythrocytes) in infected animals (Ngotho et al, 2011), but in some cases the treatment with this drug may have a hepatotoxic and nephrotoxic (Spinosa et al, 1999) effect, verified in biochemical analyses. In consequence of this, researchers have tested natural products such as essential oils and propolis extract to T. evansi (Baldissera et al, 2013(Baldissera et al, , 2014bDe Dorneles et al, 2013;Gressler et al, 2012), as well as, recently, in vitro trypanocidal activity of the extracts of Achyrocline satureioides on T. evansi (Baldissera et al, 2014a). Nanomolecule drugs present some advantages over conventional drugs, such as slow gradual controlled release, increased bioavailability and reduced toxicity (Roco, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

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Section: Introductionmentioning

confidence: 99%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

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“…The antileishmanial activity of Turkish propolis was investigated (Duran et al, 2011), and the two samples tested had IC 50 values of 175 and 350 μg/mL. The effect of an extract of Brazilian propolis on Trypanosoma evansi was investigated (Gressler et al, 2012), and in vitro the IC 50 value for the extract was found to be 10 μg/mL, but the propolis was ineffective in curing rats infected with T. evansi. Extracts of 18 Cuban propolis extracts of different types were tested against Leishmania amazonenis (Fidalgo et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The Isolation of Antiprotozoal Compounds from Libyan Propolis

Siheri

Igoli

Gray

et al. 2014

Phytotherapy Research

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Propolis is increasingly being explored as a source of biologically active compounds. Until now, there has been no study of Libyan propolis. Two samples were collected in North East Libya and tested for their activity against Trypanosoma brucei. Extracts from both samples had quite high activity. One of the samples was fractionated and yielded a number of active fractions. Three of the active fractions contained single compounds, which were found to be 13-epitorulosal, acetyl-13-epi-cupressic acid and 13-epi-cupressic acid, which have been described before in Mediterranean propolis. Two of the compounds had a minimum inhibitory concentration value of 1.56 µg/mL against T. brucei. The active fractions were also tested against macrophages infected with Leishmania donovani, and again moderate to strong activity was observed with the compounds having IC50 values in the range 5.1-21.9 µg/mL.

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“…Gressler et al [14] studied the susceptibility of T. evansi to propolis in infected rats. Propolis was administered orally to these rats at doses of 100 -400 mg/kg daily for ten days.…”

Section: Parasitosismentioning

confidence: 99%

Propolis in Dogs: Clinical Experiences and Perspectives (A Brief Review)

Betancourt¹,

García-Contreras²,

Sánchez³

2015

OJVM

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In light of the scarcity of novel therapeutic agents that are effective, the pharmaceutical industry has found a newer source of therapeutic compounds in natural products and herbal medicine to address the current health problems in humans and animals. What is particularly promising about these agents is that they produce fewer side effects and are more cost effective than synthetic compounds. This means greater availability of these treatments particularly for less developed countries who can't afford expensive treatments. The reduced side effects also mean greater patient tolerance and increased compliance thereby yielding maximal therapeutic effect without negatively impacting on quality of life. Among the natural products more frequently employed nowadays is propolis, a resin that is routinely collected by bees (Apis mellifera). Propolis contains flavonoids, caffeic acid esters and diterpenic acids, which provide the bactericidal, antiviral and antifungal properties to this product. The use of propolis to address a variety of conditions in small animal species is beginning to play an important role in the currently available treatments. Its use appears to be an effective treatment with no side effects at low cost. This paper reviews the different applications of this compound to treat diseases in dogs.

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Susceptibility of Trypanosoma evansi to propolis extract in vitro and in experimentally infected rats

Cited by 30 publications

References 26 publications

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

The Isolation of Antiprotozoal Compounds from Libyan Propolis

Propolis in Dogs: Clinical Experiences and Perspectives (A Brief Review)

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