Susceptibility of various human cancer cell lines to nanosecond and microsecond range electrochemotherapy: Feasibility of multi-drug cocktails

Rembiałkowska, Nina; Novickij, Vitalij; Radzevičiūtė-Valčiukė, Eivina; Mickevičiūtė, Eglė; Gajewska-Naryniecka, Agnieszka; Kulbacka, Julita

doi:10.1016/j.ijpharm.2023.123485

Cited by 7 publications

(2 citation statements)

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“…Recently, novel methods and hypothesis over MDR-related cell response in the context of ECT were proposed. The utilization of multi-drug cocktails, namely, the combinations of different anticancer agents, is also possible (66). Such approach decreases the probability of drug resistance and minimizes concurrent toxicity while effectively eliminating tumor cells.…”

Section: Figurementioning

confidence: 99%

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Electrochemotherapy for head and neck cancers: possibilities and limitations

Morozas,

Malyško-Ptašinskė,

Kulbacka

et al. 2024

Front. Oncol.

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Head and neck cancer continues to be among the most prevalent types of cancer globally, yet it can be managed with appropriate treatment approaches. Presently, chemotherapy and radiotherapy stand as the primary treatment modalities for various groups and regions affected by head and neck cancer. Nonetheless, these treatments are linked to adverse side effects in patients. Moreover, due to tumor resistance to multiple drugs (both intrinsic and extrinsic) and radiotherapy, along with numerous other factors, recurrences or metastases often occur. Electrochemotherapy (ECT) emerges as a clinically proven alternative that offers high efficacy, localized effect, and diminished negative factors. Electrochemotherapy involves the treatment of solid tumors by combining a non-permeable cytotoxic drug, such as bleomycin, with a locally administered pulsed electric field (PEF). It is crucial to employ this method effectively by utilizing optimal PEF protocols and drugs at concentrations that do not possess inherent cytotoxic properties. This review emphasizes an examination of diverse clinical practices of ECT concerning head and neck cancer. It specifically delves into the treatment procedure, the choice of anti-cancer drugs, pre-treatment planning, PEF protocols, and electroporation electrodes as well as the efficacy of tumor response to the treatment and encountered obstacles. We have also highlighted the significance of assessing the spatial electric field distribution in both tumor and adjacent tissues prior to treatment as it plays a pivotal role in determining treatment success. Finally, we compare the ECT methodology to conventional treatments to highlight the potential for improvement and to facilitate popularization of the technique in the area of head and neck cancers where it is not widespread yet while it is not the case with other cancer types.

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Section: Figurementioning

confidence: 99%

“…MDR may also be managed through modulation of PEF parameters. Shorterduration electric pulses (nanosecond range) were shown to be more effective in countering drug resistance mechanisms compared to conventional European Standard Operating Procedures of Electrochemotherapy (ESOPE) protocols employing 100-µs pulse trains (66).…”

Section: Figurementioning

confidence: 99%

Electrochemotherapy for head and neck cancers: possibilities and limitations

Morozas,

Malyško-Ptašinskė,

Kulbacka

et al. 2024

Front. Oncol.

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Enhancing lung cancer growth inhibition with calcium ions: Role of mid- and high-frequency electric field pulses

Rembiałkowska,

Kucharczyk,

Radzevičiūtė-Valčiukė

et al. 2024

Biomedicine & Pharmacotherapy

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Peroxiredoxin I and II as novel therapeutic molecular targets in cervical cancer treatment through regulation of endoplasmic reticulum stress induced by bleomycin

Sun,

Ma,

Guo

et al. 2024

Cell Death Discov.

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Cervical cancer, significantly affecting women worldwide, often involves treatment with bleomycin, an anticancer agent targeting breast, ovarian, and cervical cancers by generating reactive oxygen species (ROS) to induce cancer cell death. The Peroxiredoxin (PRDX) family, particularly PRDX1 and 2, plays a vital role in maintaining cellular balance by scavenging ROS, thus mitigating the damaging effects of bleomycin-induced mitochondrial and cellular oxidative stress. This process reduces endoplasmic reticulum (ER) stress and prevents cell apoptosis. However, reducing PRDX1 and 2 levels reverses their protective effect, increasing apoptosis. This research highlights the importance of PRDX1 and 2 in cervical cancer treatments with bleomycin, showing their potential to enhance treatment efficacy by managing ROS and ER stress and suggesting a therapeutic strategy for improving outcomes in cervical cancer treatment.

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Susceptibility of various human cancer cell lines to nanosecond and microsecond range electrochemotherapy: Feasibility of multi-drug cocktails

Cited by 7 publications

References 50 publications

Electrochemotherapy for head and neck cancers: possibilities and limitations

Electrochemotherapy for head and neck cancers: possibilities and limitations

Enhancing lung cancer growth inhibition with calcium ions: Role of mid- and high-frequency electric field pulses

Peroxiredoxin I and II as novel therapeutic molecular targets in cervical cancer treatment through regulation of endoplasmic reticulum stress induced by bleomycin

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