Susceptibility pattern of healthcare-associated methicillin resistant staphylococcus aureus to Vancomycin and Daptomycin

Abstract

exhibited a potent post-antibiotic effect when compared to Vancomycin. In order to elucidate their mechanism of action, resistant mutants with a MIC of 64 mg/L were generated (frequency ∼10 -7 ) and are being characterized at the molecular level to decipher mechanism of action of these compounds. Conclusion:A series of 2-Aryl indole-based 2,3-epoxy-1,4naphthoquinones have been synthesized with potent anti-MRSA activity. These compounds potentially deplete thiols, thus enhancing ROS in bacteria, which might help in overcoming drug resistance.