Susceptibility status of major malaria vectors to novaluron, an insect growth regulator South-Eastern Tanzania

Ngonzi, Amos J.; Muyaga, Letus L.; Ngowo, Halfan S.; Urio, Naomi; Vianney, John-Marry; Lwetoijera, Dickson W.

doi:10.11604/pamj.2022.41.273.33793

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Insect growth regulators (IGRs) are a group of chemicals that have been recently used as an effective alternative for controlling insect vectors worldwide 7 . They exhibit a good margin of safety to most non-target biota, thus offering some advantages in mosquito control programmes 26 and are strictly arthropod-specific and environmentally safe and show very low toxicity to birds, mammals and honey bees 24 , 46 . Novaluron 10 EC formulation has been developed under WHOPES guidance and supervision, as an IGR against insects, including mosquitoes 24 , 25 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of the insect growth regulator novaluron in the control of dengue vector mosquitoes Aedes aegypti and Ae. albopictus

Herath,

De Silva,

Weeraratne

et al. 2024

Sci Rep

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Insect Growth Regulator (IGR) novaluron is an alternative to synthetic neuro-inhibitory insecticides. Present study was designed to assess appropriate dosages of novaluron for dengue vector control. Larvae of Aedes aegypti and Ae. albopictus were exposed to a concentration series of novaluron (Rimon EC10) for two fixed exposure periods of 7-days and 14-days to determined LC50 and LC99 values. Inhibition of adult emergence (IE50 and IE99) was determined by a 14-day exposure. Semi-field experiments were conducted by exposing cohorts of Ae. aegypti larvae to IE99, 2 × IE99 and 10 × IE99 novaluron concentrations in water storage buckets (10 L) and plastic barrels (200 L). For the 7-day exposure, LC50 values were 0.047–0.049 ppm and LC99 were 0.144–0.151 ppm. For 14-day exposure, these values were 0.002–0.005 ppm and 0.006–0.01 ppm respectively. For both species, IE99 was 0.001 ppb under semi-field conditions, and was effective for nearly 2 months. Novaluron concentration 0.01 ppb was effective up to 3 months, with an IE of 89–95%. Authorities should critically review a reduction of the presently recommended field dosage of 200 ppm novaluron by × 100 or more. This would provide the same efficacy but mitigate environmental pollution, development of vector resistance, and financial losses.

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Section: Discussionmentioning

confidence: 99%

Efficacy of the insect growth regulator novaluron in the control of dengue vector mosquitoes Aedes aegypti and Ae. albopictus

Herath,

De Silva,

Weeraratne

et al. 2024

Sci Rep

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“…gambiae and An. funestus under semi-field settings have proven to be susceptible to novaluron 95 . Furthermore, it is extremely important that future research should look at the possibility to other explore alternative IGRs that could be used for autodissemination approach in rotation with pyriproxyfen.Habitat-based modelling by Gu and Novak highlighted that in order to combat malaria in Africa, larval interventions should be focused in identifying and targeting prolific habitats 96 , a task that might be accomplished with near perfection using autodissemination approach, based on the evidence that gravid mosquitoes know better their most preferred habitats 71 , 72 .…”

Section: Potential Integration To Current Malaria Interventionsmentioning

confidence: 99%

Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa

Mmbaga,

Lwetoijera

2023

Wellcome Open Res

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Despite the progress made in reducing malaria burden, new ways to address the increasing challenges of insecticide resistance and the invasion and spread of exotic malaria vectors such as Anopheles stephensi in Africa are urgently needed. While African countries are adopting larviciding as a complementary intervention for malaria vector control, the autodissemination technology has the potential to overcome barriers associated with the identification and treatment of prolific habitats that impede conventional larviciding approaches in rural settings. The autodissemination technology as a “lure and release” strategy works by exploiting the resting behavior of gravid mosquitoes to transfer lethal concentration of biological or chemical insecticide such as pyriproxyfen (PPF), an insect growth regulator (IGRs) to their oviposition sites and result in adult emergence inhibition. Despite the evidence of the autodissemination approach to control other mosquito-borne diseases, there is growing and promising evidence for its use in controlling malaria vectors in Africa, which highlights the momentous research that needs to be sustained. This article reviews the evidence for efficacy of the autodissemination approach using PPF and discusses its potential as efficient and affordable complementary malaria vector control intervention in Africa. In the previous studies that were done in controlled semi-field environments, autodissemination with PPF demonstrated its potential in reducing densities of captive population of malaria vectors such as Anopheles gambiae and Anopheles arabiensis. Of importance, empirical evidence and biology-informed mathematical models to demonstrate the utility of the autodissemination approach to control wild populations of malaria vectors under field environment either alone or in combination with other tools are underway. Among others, the key determining factors for future introduction of this approach at scale is having scalable autodissemination devices, optimized PPF formulations, assess its integration/complementarity to existing conventional larviciding, and community perception and acceptance of the autodissemination approach.

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Susceptibility status of major malaria vectors to novaluron, an insect growth regulator South-Eastern Tanzania

Cited by 2 publications

References 25 publications

Efficacy of the insect growth regulator novaluron in the control of dengue vector mosquitoes Aedes aegypti and Ae. albopictus

Efficacy of the insect growth regulator novaluron in the control of dengue vector mosquitoes Aedes aegypti and Ae. albopictus

Current and future opportunities of autodissemination of pyriproxyfen approach for malaria vector control in urban and rural Africa

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