Susceptibility to allergy in adoptive children: a cross-sectional study at “Bambino Gesù Children’s Hospital”

Tchidjou, Hyppolite K.; Vescio, Maria Fenicia; Serafinelli, Jessica; Giampaolo, Rosaria; Jenkner, Alessandro; Tadonkeng, Mathurin C; Avellis, Luca; Fiocchi, Alessandro; Pezzotti, Patrizio; Rezza, Giovanni; Rossi, Paolo

doi:10.1186/s13052-017-0440-2

Cited by 7 publications

(7 citation statements)

References 31 publications

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“…The primary search identified 749 records. The titles and abstracts were screened, 41 full-text papers were assessed for eligibility, and 19 studies fulfilled our inclusion criteria (Table 1) (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). These studies were conducted between 1988 and 2016 and covered 7663 children aged between 1.1 and 5.7 years, who were adopted from Asia, Eastern Europe, Africa and South and Central America.…”

Section: Resultsmentioning

confidence: 99%

“…The percentage of adopted children with protective antibody titres for diphtheria, tetanus, pertussis, hepatitis B, measles, mumps, rubella and varicella varied in the published studies that we examined. Tetanus protective antibody levels were observed in 35–95% of adopted children, and similar data were reported for diphtheria . A higher percentage of adoptees had protective antibody levels for polio and measles, varying from 57 to 90% and 36 to 90%, respectively .…”

Section: Discussionmentioning

confidence: 99%

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Systematic review shows that immunising internationally adopted children is a major challenge for primary health care

et al. 2018

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Aim This systematic review aimed to provide an overview of the immunisation of internationally adopted children and to discuss possible vaccination strategies. Methods A literature search was performed covering papers published in English from 1988 to 15 June 2018 using the Ovid MEDLINE, EMBASE and Cochrane Library databases. This identified 749 studies and 41 full texts were evaluated. Results Overall, 19 studies conducted between 1988 and 2016 fulfilled our inclusion criteria. These covered 7663 children aged 1.1–5.7 years adopted from Asia, Eastern Europe, Africa and South and Central America. Tetanus protective antibody levels ranged from 35 to 95%, and similar data were reported for diphtheria. A higher percentage of adoptees had protective antibody levels for polio (50–93%) and measles (62–95%). More than a third (35%) did not have protective antibody titres for hepatitis B. Only one study investigated adoptees with protective antibodies against haemophilus influenza, and it reported that this was around 66%. Conclusion The appropriate immunisation of internationally adopted children is a major challenge for primary health care and a number of different approaches have been suggested, with no clear conclusions. Further studies on the cost‐effectiveness of different approaches should be performed to optimise screening strategies and develop recommendations.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Systematic review shows that immunising internationally adopted children is a major challenge for primary health care

et al. 2018

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“…Research from Italy showed a high prevalence of atopic disorders in immigrants from extra-European countries, with a similar spectrum of sensitization to the Italian population, but possibly greater severity and among children more prevalent allergic rhinitis [ 45 – 48 ]. A further study in adoptive children examined soon after arrival in their new home country showed sensitizations (based on serum IgE analyses against food and inhalant allergens in 30 and 34%, respectively [ 49 ].Overall our results on sensitizations are in line with those reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

High burden of atopy in immigrant families in substandard apartments in Sweden – on the contribution of bad housing to poor health in vulnerable populations

Richter

Jakobsson

Taj

et al. 2018

World Allergy Organization Journal

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BackgroundAtopic disorders are a global concern. Studies in migrant populations can illuminate the interplay of genetic and environmental factors. Exposures related to bad housing (indoor dampness, mould growth, crowding etc.) are likely to play a role in how socioeconomic inequalities can turn into health disparities for disadvantaged populations. The sizable immigrant population living in very poor-quality housing in Malmö, Sweden, became the focus of a cross-sectional study.ObjectiveTo describe atopic disorders and sensitizations in a population living in substandard housing in Malmö, Sweden, with an emphasis on their relation to harmful exposures from the built environment.MethodsFamilies were recruited via identification of any children with symptomatic airway afflictions from health care records, and also asymptomatic children from school lists. Interviewer-led health questionnaire data and data from self-reports about living conditions were obtained together with data from home inspections carried out by health communicators. Families underwent skin prick tests (SPT) against common aeroallergens.ResultsAs could be expected from background demographic information, it turned out that we effectively studied an immigrant population inhabiting very precarious housing outside the center of Malmö. A total of 359 children from 130 families (total 650 participants) were included. Overall the prevalence of potentially harmful environmental exposures was high (signs of moisture or mould in more than 50% of apartments, indoor smoking in 37% of households). Atopic disorders were common among both adults and children. SPTs showed a spectrum of sensitizations consistent with unselected populations in Sweden. Paternal sensitization in the SPT was associated with higher risk of sensitization for offspring than maternal sensitization. Few statistically significant associations of atopic sensitization with studied environmental exposures were detected (for example objective signs of dampness /mould in bathrooms). There were marked discrepancies between asthma diagnoses obtained from the health records and parental reports of such diagnoses and treatment for their children.ConclusionsThe atopic burden in this selected immigrant population was high, and results point to unmet medical needs. Health care systems caring for such populations need to be aware of their specific health needs; comprehensive asthma and allergy care should include consideration of harmful environmental exposures, adhering to the precautionary principle.

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“…Several studies on migrating families revealed a big discrepancy in the prevalence of food allergy if there is a mismatch between the pre-conception, antenatal and postnatal environment. For example, if the mother conceives and gives birth in a new country, the baby has a higher risk of food allergy and AD compared to babies who were born in the country of maternal origin ( 136 , 137 ). This amply illustrates that environmental factors rather than genetics had contributed to the increasing prevalence of food allergy.…”

Section: Unmet Need and Future Researchmentioning

confidence: 99%

Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy

Zepeda-Ortega¹,

Goh

Xepapadaki

et al. 2021

Front. Immunol.

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The prevalence of food allergy has increased over the last 20-30 years, including cow milk allergy (CMA) which is one of the most common causes of infant food allergy. International allergy experts met in 2019 to discuss broad topics in allergy prevention and management of CMA including current challenges and future opportunities. The highlights of the meeting combined with recently published developments are presented here. Primary prevention of CMA should start from pre-pregnancy with a focus on a healthy lifestyle and food diversity to ensure adequate transfer of inhibitory IgG- allergen immune complexes across the placenta especially in mothers with a history of allergic diseases and planned c-section delivery. For non-breastfed infants, there is controversy about the preventive role of partially hydrolyzed formulae (pHF) despite some evidence of health economic benefits among those with a family history of allergy. Clinical management of CMA consists of secondary prevention with a focus on the development of early oral tolerance. The use of extensive Hydrolysate Formulae (eHF) is the nutrition of choice for the majority of non-breastfed infants with CMA; potentially with pre-, probiotics and LCPUFA to support early oral tolerance induction. Future opportunities are, among others, pre- and probiotics supplementation for mothers and high-risk infants for the primary prevention of CMA. A controlled prospective study implementing a step-down milk formulae ladder with various degrees of hydrolysate is proposed for food challenges and early development of oral tolerance. This provides a more precise gradation of milk protein exposure than those currently recommended.

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Susceptibility to allergy in adoptive children: a cross-sectional study at “Bambino Gesù Children’s Hospital”

Cited by 7 publications

References 31 publications

Systematic review shows that immunising internationally adopted children is a major challenge for primary health care

Systematic review shows that immunising internationally adopted children is a major challenge for primary health care

High burden of atopy in immigrant families in substandard apartments in Sweden – on the contribution of bad housing to poor health in vulnerable populations

Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy

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