Susceptibility to cartap-induced lethal effect and diaphragmatic injury via ocular exposure in rabbits

Liao, Jiunn‐Wang; Pang, Victor Fei; Jeng, Chian-Ren; Chang, Su-Wei; Hwang, Jenn-Sheng; Wang, Shun-Cheng

doi:10.1016/s0300-483x(03)00268-3

Cited by 15 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10,11 Moreover, cartap can cause Ca 2+ -dependent contracture in both isolated mouse and rabbit phrenic nerve diaphragms, and cartap-induced reactive oxygen species (ROS) generation through a Ca 2+ -dependent mechanism may play a central role in the myogenic contracture and myofiber injury of diaphragm leading to respiratory failure and subsequent death in rabbits. [12][13][14] These findings coincide with the clinical course of human acute poisoning by cartap ingestion.…”

Section: Discussionsupporting

confidence: 72%

Fatal human poisoning with Padan^TM: a cartap-containing pesticide

Kurisaki

Kato

Ishida

et al. 2010

Clinical Toxicology

View full text Add to dashboard Cite

We report a patient who ingested about 13 g of Padan SG, a cartap-containing pesticide. After ingestion, the patient developed multiple seizures and dyspnea and lost consciousness. The patient did not recover and died on the fifth hospital day despite treatment at the early stage of poisoning. The cause of death was multisystem organ failure. Results of toxicological analysis were as follows: concentrations of nereistoxin (cartap metabolite) were 10.6 microg/mL in plasma, 18.2 microg/mL in urine, and 2.6 mg/mL in gastric fluid. Results of drug screening of urine by Triage DOA Panels and using an organophosphate detection kit were negative.

show abstract

Section: Discussionsupporting

confidence: 72%

Fatal human poisoning with Padan^TM: a cartap-containing pesticide

Kurisaki

Kato

Ishida

et al. 2010

Clinical Toxicology

View full text Add to dashboard Cite

show abstract

“…Although it is known to be of moderate toxicity, Gupta et al says that it becomes toxic if consumed more than 75 ml of solution containing 50% Cartap along with alcohol [10]; that is, 3.75 g. All of our patients had consumed more than that. Although Lao in his initial studies says that Cartap is a safe compound with oral LD 50 in monkey being 100-200 mg/kg body wt [4], his later findings demonstrated diaphragmatic contracture and death of rabbit on ocular installation [3].…”

Section: Discussionmentioning

confidence: 99%

“…It produces its toxic effects by affecting neuromuscular function [2]. It is described as high effectiveness, low residue pesticide; however, when severe can result in respiratory failure and death [3]. In India, it is available in two forms 4% granular form and 50% water soluble powder form.…”

Section: Introductionmentioning

confidence: 99%

An Observational Study of 11 Cases of Cartap Poisoning - A Rare Poisoning

Das¹,

Mohanty²,

Behera

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Cartap hydrochloride poisoning is an uncommon poisoning encountered in India. The aim of this study was to assess the characteristics, severity, management, and outcome of patients with Cartap poisoning, treated with N-acetylcysteine (NAC) in intensive care unit (ICU) of a tertiary referral hospital.Methods: This is a retrospective study where 11 cases of Cartap poisoning admitted to hospital ICU between 2011 and 2016 were identified from the case records. The demographic data, mode of ingestion, time to treat, ingested dose and severity of poisoning, presenting features, duration of mechanical ventilation (MV), dose of NAC used, complications, and outcome were noted.Results: Patients were scored as moderate or severe cases of poisoning. Severe cases consumed >10 g, underwent gastric lavage > 4 hrs, and took Cartap concomitantly with alcohol or in empty stomach. Duration of MV varied from 68-94 hrs in severe cases and 12-48 hrs in moderate cases. Average dose of NAC in severe case was 11.19 g and moderate case was 8.89 g. The most common presenting symptoms were vomiting, altered sensorium, and breathlessness. Severe cases had more complications, and the most common complication was hypotension followed by seizures. Survival was 100%.Conclusion: 50% of Cartap poisoning cases had good survival outcome. Severity of poisoning depends on amount of Cartap ingested, time taken for gastric lavage, and concomitant administration of alcohol. Duration of MV and dose of NAC and complications encountered correlates with the severity of poisoning.

show abstract

“…1) were developed from NTX and have been commonly used in agriculture due to their low mammalian toxicity and high effectiveness. However, subsequent studies have indicated that they pose potential toxicological risk to humans, not only for their acute toxicity, but also for their potential ontogenetic developmental toxicity, especially cartap [5][6][7][8][9][10]. These NTX-related insecticides are hydrolyzed to NTX in insects and in the human body [11].…”

Section: Introductionmentioning

confidence: 99%