Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus

Abstract

37Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes fatal encephalitis in humans.

Tick-borne encephalitis in Japan, Republic of Korea and China

“…These findings indicated that the Oshima strain was more susceptible to the antiviral activity of Oas1b against neurovirulence. 36 …”

Tick-Borne Flaviviruses and the Type I Interferon Response

“…Several polymorphisms in the OAS genes have been shown to correlate with severe forms of TBE in patients [ 154 ]. Also, the murine isoform Oas1b , which is often lacking in inbred mice strains, confers strain dependent resistance against neurovirulence from far eastern TBEV [ 155 ]. Two other ISGs which have been shown to be antivirally active against TBEV are virus inhibitory protein endoplasmic reticulum associated interferon inducible (viperin) and tripartite motif-79α (TRIM79α).…”