Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes

Susceptibility to HIV‐1 infection is influenced by toll like receptor‐2 (−196 to −174) polymorphism in a north Indian population

“…The results of the present study showed that all three nonsynonymous TLR2 gene polymorphisms were rare in our study population. Our study is in agreement with previous studies from India conducted in patients with tuberculosis, juvenile idiopathic arthritis and systemic lupus erythematosus . Our data are further supported by previous studies showing that these SNPs are absent in an Asian population, such as those from Taiwan and South Korea, as well as in a Chinese Han population, one African cohort from Ethiopia and an American cohort from Colombia …”

Clinical significance of the single nucleotide polymorphism TLR2 R753Q in heart transplant recipients at risk for cytomegalovirus disease

“…The relative frequency of the heterozygous TLR2 R753Q polymorphism varies with geographic region and population studied -0% in Asia [20,21], 9% in the US [10], and 1.3%-11.4% in Europe [22][23][24][25][26][27]. In concordance, we found a relative frequency of the heterozygous polymorphism of 5.7% and of the homozygous mutated polymorphism of 0.4% in the general Austrian population.…”

Polymorphisms within Genes Involved in Regulation of the NF-κB Pathway in Patients with Rheumatoid Arthritis

“…The T allele of TLR9 gene polymorphism (rs5743836, −1237 C > T) was found to act as a risk factor of systemic lupus erythematosus (SLE) in South Indian Tamils [ 18 ]. The inconsistent results of this report and the present study stem from ethnic and sex from differences between studied populations.…”