Susceptibility-Weighted Magnetic Resonance Imaging in the Evaluation of Dementia

Abstract

An 88-year-old woman with a clinical diagnosis of Alzheimer's disease and advanced dementia, was evaluated with standard MRI of the brain as well as Susceptibility Weighted Imaging (SWI) with the MRI. SWI revealed more extensive brain microhemorrhages than standard MRI techniques, allowing the radiologic diagnosis of cerebral amyloid angiopathy. SWI shows promise as a more sensitive diagnostic tool than standard brain MRI for the evaluation of patients with dementia.

Three-dimensional pseudocontinuous arterial spin labeling and susceptibility-weighted imaging associated with clinical progression in amnestic mild cognitive impairment and Alzheimer's disease

“…[20] In the present study, iron deposition in the bilateral basal ganglia area in AD group was higher than aMCI group, and was consistent with previous studies. [18,19] We also found multiple lobar MBs in the bilateral lobe regions, but in brainstem/cerebellum no significant difference was noted between aMCI and AD group.…”

“…Microhemorrhages might be a cause of progressive cognitive impairment in the previous research. [19] Susceptibility-weighted imaging (SWI) sequences are much more sensitive for the detection of haemorrhagic than non-contrast CT scan and GE-T2∗ MRI technique. [20] SWI has been widely used in the evaluation of neurodegenerative diseases, vascular malformations, tumors trauma and cerebral amyloid angiopathy.…”

Lipocalin 2 als liquor und plasmabasierter Biomarker bei vaskulärer Enzephalopathie: Assoziationen mit klinischen Merkmalen und verschiedenen Formen der vaskulären Demenz

“…Neue Läsionen führen zu einer steilen Zunahme insbesondere motorischer und exekutiver Defizite (Pantoni 2002;Jokinen et al 2011;Maillard et al 2012;Iadecola 2017). WMLs lassen sich als Hyperintensitäten in einer T2-oder Fluid Attenuated Inversion Recovery-(FLAIR-) Wichtungen darstellen und Mikroblutungen zeigen sich als Hypointensitäten in einer T2 oder Susceptibility-Weighted Imaging-(SWI-) Wichtung (Kantarci et al 2002;Larsen et al 2007;Lawrence et al 2013;Sharma et al 2021). Arteriosklerotisch veränderte Gefäße sind bilddiagnostisch charakteristisch von erweiterten perivaskulären Räumen umgeben (Brown und Thore 2011).…”