Susceptible and protective major histocompatibility complex class II alleles in early-onset pauciarticular juvenile chronic arthritis

Determination of the peptide binding motif and high-affinity ligands for HLA-DQ4 using synthetic peptide libraries

“…Combinatorial peptide libraries have been used successfully to give insight into peptide binding requirements of MHC class II molecules [18,19]. The determination of the peptide binding motif of HLA-DQ4 is of special interest as its association with one subtype of JIA has been described [6,7].…”

“…The genetic analysis of the various JIA subgroups has been complicated by different classification schemes for juvenile idiopathic arthritic diseases. However, for the oligoarthritic manifestation as classified by both the EULAR (European League against Rheumatism) and the ILAR (International League of Associations for Rheumatology) criteria, a strong association has been found for the HLA class II haplotypes DQA1*0401/DQB1*0402 and DQA1*0501/DQB1*0301 [6,7]. Recently a differential peptide binding motif for three HLA-DQ molecules positively and negatively associated with JIA was published [8].…”

Identification of a genetic risk factor for systemic juvenile rheumatoid arthritis in the 5?-flanking region of the TNF? gene and HLA genes

“…Using the criteria of the American College of Rheumatology (ACR) (1), this disease can be subdivided into 3 major categories, i.e., systemic, pauciarticular, and polyarticular, suggesting that JRA is a heterogeneous disease with different genetic backgrounds for each clinical subtype. There are several reports addressing the association between JRA and various alleles of HLA genes (2)(3)(4); for example, early-onset pauciarticular juvenile chronic arthritis has been reported to be associated with HLA-A2, DR5, DR6, DR8, DQA*0101, DQA*0401, DQA*0501, DQA*0601, and DPB1*0201 (5,6). However, the genetic factors involved in the susceptibility to or severity of each type of JRA remain to be fully addressed.…”

Juvenile idiopathic arthritis characteristics: Etiology and pathophysiology

“…5,6 A number of HLA studies have been performed showing that the Class II antigens HLA-DRB1n11 (a subtype of HLA-DR5) and HLA-DRB1n08 are strongly associated to early onset oligoarticular JIA. 7,8 HLA-DRB1n08 is also associated with RF-negative polyarticular arthritis. 9 RF-positive polyarticular JIA is immunogenetically similar to adult rheumatoid arthritis (RA) with a confirmed association with HLA-DR4.…”