Suspected Isolated Pancreatic Lipase Deficiency in a Dog

Xenoulis, Panagiotis G.; Fradkin, Jonathan M.; Rapp, Steven W.; Suchodolski, Jan S.; Steiner, Jörg M.

doi:10.1892/0891-6640(2007)21[1113:sipldi]2.0.co;2

Cited by 2 publications

(5 citation statements)

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“…After a complete work‐up, all puppies were diagnosed with a suspected isolated pancreatic enzyme deficiency. The clinical history, physical exam findings, and diagnostic testing were remarkably constant in all 3 dogs, as well as consistent with the initial case report in a 4‐month‐old puppy . All dogs were reported to have a lifelong history of diarrhea, which was initially noted by the owners and evaluated by a veterinarian between 8–12 weeks of age.…”

Section: Discussionsupporting

confidence: 79%

“…Therefore, in dogs with clinical signs of maldigestion a significant loss in exocrine pancreatic function is likely. All 3 dogs developed clinical signs at a much younger age than most dogs with EPI, further supporting that an isolated pancreatic enzyme deficiency in dogs is a congenital condition distinct from EPI …”

Section: Discussionmentioning

confidence: 71%

“…Isolated pancreatic lipase deficiencies (IPLD) are rare in dogs based on the paucity of reported cases. There is a single case report describing a 4‐month‐old puppy with a suspected isolated pancreatic enzyme deficiency . The puppy had clinical signs suggestive of EPI but normal serum TLI concentration (7.1 μg/L).…”

Section: Discussionmentioning

confidence: 99%

“…One week after fenbendazole the dog's feces normalized. However, 3 days later the owner reported the dog's watery diarrhea returned, and based on the dog's PLI below the limit of detection (<30 μg/L, reference interval 30–200 μg/L) a trial on PES (0.75 teaspoons with each meal) was initiated for a suspected isolated pancreatic enzyme deficiency . Three weeks after supplementing the dog's meal with pancreatic enzymes, the owner reported that the dog's diarrhea had promptly resolved and its haircoat was normal for the first time.…”

Section: Casementioning

confidence: 99%

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Suspected Isolated Pancreatic Enzyme Deficiencies in Dogs

Viviano

Ziglioli

2013

Veterinary Internal Medicne

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A 6-month-old, male intact, German Shepherd Dog (GSD) was examined for a 3 month history of chronically loose feces since the owner acquired him at 12 weeks of age. Over the 3 month period the dog maintained an excellent appetite with little weight gain and had persistently abnormal feces. The consistency of feces ranged from soft to liquid diarrhea. The dog tested positive for Giardia spp. on multiple occasions despite multiple treatments with fenbendazole and metronidazole. Additional therapies including tylosin and probiotics resulted in transient or no improvement. Two weeks before examination, the dog started vomiting once every 5 days.On examination, the dog weighed 22 kg with a body condition score of 3/9. Physical abnormalities included brachygnathism with malocclusion lesions on the lower lip and hard palate, erythema with occasional pustules on its ventrum, consistent with a superficial pyoderma, and pain when extending both hips suggestive of bilateral hip dysplasia. Abdominal palpation was nonpainful and rectal examination revealed only soft feces of normal color. Complete blood count (CBC), serum chemistry, and electrolytes were within the reference interval with the exception of a mild increase in serum phosphorus (7.6 mg/dL; reference interval, 2.1-6.3 mg/dL), which was consistent with the dog's age. Abdominal ultrasound examination did not reveal abnormalities. The spleen was mottled and multiple lymph nodes were visible, but of normal echogenicity and consistent with dog's age. Serum concentrations of bile acids before and after eating were 1.6 lmol/L (reference interval 0-28 lmol/L) and <1.0 lmol/L (reference interval 0-28 lmol/L), and cortisol (2.3 lg/dL, reference interval 1-5 lg/dL), cobalamin (513 ng/L; reference interval 251-908 ng/L), and folate (20.7 lg/L, reference interval 7.7-24.4 lg/L) were all within the reference interval. The dog's serum pancreatic lipase immunoreactivity (cPLI) a was less than the lower limit of detection (<30 lg/L, reference interval 30-200 lg/L) and trypsin-like immunoreactivity (TLI) was below the reference interval (5.2 lg/L, reference interval 5.7-45.2 lg/L), a level not associated with clinical signs of exocrine pancreatic insufficiency (EPI).

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Casementioning

confidence: 99%

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Suspected Isolated Pancreatic Enzyme Deficiencies in Dogs

Viviano

Ziglioli

2013

Veterinary Internal Medicne

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“…In that study, only one of the 74 healthy dogs had a cPLI result below the reference interval. More importantly, determination of serum cPLI concentration using the original cPLI ELISA has been shown to be useful for the diagnosis of isolated pancreatic lipase deficiency, a rare form of EPI in dogs that cannot be diagnosed by use of TLI . However, the original cPLI ELISA is no longer available.…”

Section: Clinical Performance Characteristics Of Serum Canine Pli Assaysmentioning

confidence: 99%

Canine and feline pancreatic lipase immunoreactivity

Xenoulis

Steiner

2012

Veterinary Clinical Pathol

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The diagnosis of pancreatitis in dogs and cats can be challenging. Several diagnostic tests have been evaluated over the years, but the majority have been shown to be of limited utility owing to poor performance or limited availability or because invasive procedures are required. Assays for the measurement of pancreatic lipase immunoreactivity (cPLI for dogs and fPLI for cats) were first developed over a decade ago and now include Spec cPL and SNAP cPL for dogs and Spec fPL and SNAP fPL for cats. Owing to their high sensitivity and specificity for pancreatitis compared with those of other serum tests, concentrations of cPLI and fPLI have been demonstrated to be the serum tests of choice for evaluation of dogs and cats, respectively, suspected of having pancreatitis. False-positive and false-negative results can occur, and recognition of the limitations of pancreatic lipase immunoreactivity assays is important. As there is currently no gold standard for antemortem diagnosis of pancreatitis in dogs and cats, the combination of a complete history and physical examination, measurement of pancreatic lipase immunoreactivity, and ultrasonographic examination of the pancreas is the best approach for an accurate noninvasive diagnosis of pancreatitis.

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Suspected Isolated Pancreatic Lipase Deficiency in a Dog

Cited by 2 publications

References 0 publications

Suspected Isolated Pancreatic Enzyme Deficiencies in Dogs

Suspected Isolated Pancreatic Enzyme Deficiencies in Dogs

Canine and feline pancreatic lipase immunoreactivity

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