Suspected-target screening for the assessment of plastic-related chemicals in honey

Eyken, Annie von; Ramachandran, Swaroopini; Bayen, Stéphane

doi:10.1016/j.foodcont.2019.106941

Cited by 22 publications

(10 citation statements)

References 52 publications

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“…This demonstrates that most plastic chemicals remain unknown. Similarly, another study analyzed the compounds migrating from plastic and glass jars and found that 99% remained unidentified . The low identification rates are even more true given that our approach may result in many false-positive annotations as indicated by the identification of a number of implausible compounds in plastics ( e.g ., pharmaceuticals).…”

Section: Resultsmentioning

confidence: 99%

Plastic Products Leach Chemicals That Induce In Vitro Toxicity under Realistic Use Conditions

Zimmermann

Bartošová

Braun

et al. 2021

Environ. Sci. Technol.

148

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Plastic products contain complex mixtures of extractable chemicals that can be toxic. However, humans and wildlife will only be exposed to plastic chemicals that are released under realistic conditions. Thus, we investigated the toxicological and chemical profiles leaching into water from 24 everyday plastic products covering eight polymer types. We performed migration experiments over 10 days at 40 °C and analyzed the migrates using four in vitro bioassays and nontarget high-resolution mass spectrometry (UPLC-QTOF-MS E ). All migrates induced baseline toxicity, 22 an oxidative stress response, 13 antiandrogenicity, and one estrogenicity. Overall, between 17 and 8681 relevant chemical features were present in the migrates. In other words, between 1 and 88% of the plastic chemicals associated with one product were migrating. Further, we tentatively identified ∼8% of all detected features implying that most plastic chemicals remain unknown. While low-density polyethylene, polyvinyl chloride, and polyurethane induced most toxicological endpoints, a generalization for other materials is not possible. Our results demonstrate that plastic products readily leach many more chemicals than previously known, some of which are toxic in vitro. This highlights that humans are exposed to many more plastic chemicals than currently considered in public health science and policies.

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Section: Resultsmentioning

confidence: 99%

Plastic Products Leach Chemicals That Induce In Vitro Toxicity under Realistic Use Conditions

Zimmermann

Bartošová

Braun

et al. 2021

Environ. Sci. Technol.

148

View full text Add to dashboard Cite

show abstract

“…Are honey bees eventually at risk due to exposure in MPs? A lot of different chemical compounds have been detected in honey samples, such as styrene [36], plasticizers (phthalates [36,139] and DEHA [140]), bisphenol A [36,139], TBOEP (flame retardant) [140], and microplastics [9,10]. In studies where honey bees were exposed to PS MPs, showed sublethal effects.…”

Section: Chemical Compounds In Honey-general Overviewmentioning

confidence: 99%

Honey Quality and Microplastic Migration from Food Packaging: A Potential Threat for Consumer Health?

et al. 2022

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In ancient Greece, people said that “honey is the Food of the Gods”, and they were right. They believed that honey fell from the sky, with the morning dew, on the flowers and leaves, and from this point, the bees collected it. Honey is one of the most nutritious food products, which can be found in most homes. A lot of honey products are stored in different types of packaging materials, including plastics. Plastic packaging has been studied for the migration of plasticizers, chemical compounds, and MPs and NPs in foodstuffs. Most of them have been achieved through food simulations, while some studies managed to detect and isolate MPs/NPs. Recent studies presented evidence for the presence of MPs/NPs in honey products but not directly connected to food packaging or to the different types of honey and their properties (viscosity, pH value, and moisture content) or their storing conditions (temperature, humidity, light, and time). Spectroscopic and analytical techniques like Raman, FTIR, HPLC, and GC-MS are in the foreground for MP/NP detection and identification, but a universal way of isolation, detection, characterization, and quantification has not yet been found. This leaves an open field for more work to be done to clarify the factors affecting the migration of plastic packaging material in honey.

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“…Recently, von Eyken et al. developed an untargeted metabolomics screening of plastic migrants in honey samples, commercialized in both glass and plastic jars, by HPLC-Q-TOF-MS/MS after a simple sample preparation approach constituted by dilution of the pure matrix with a mixture of acetonitrile and water, filtration, and further dilution with water until a 1% honey extract is obtained . Data analysis allowed the identification of 662 putative potential plastic migrants and two of them, 2-ethyhexyladipate (DEHA) and tris (2-butoxyethyl) phosphate (TBOEP), were confirmed and quantified by using analytical standards.…”

Section: Foodomics Applicationsmentioning

confidence: 99%

Foodomics: Analytical Opportunities and Challenges

et al. 2021

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Suspected-target screening for the assessment of plastic-related chemicals in honey

Cited by 22 publications

References 52 publications

Plastic Products Leach Chemicals That Induce In Vitro Toxicity under Realistic Use Conditions

Plastic Products Leach Chemicals That Induce In Vitro Toxicity under Realistic Use Conditions

Honey Quality and Microplastic Migration from Food Packaging: A Potential Threat for Consumer Health?

Foodomics: Analytical Opportunities and Challenges

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