Suspended animation in cooled, supercooled and frozen rats

Andjus, Radoslav K.

doi:10.1113/jphysiol.1955.sp005324

Cited by 50 publications

(11 citation statements)

References 7 publications

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“…This is a very important fact both for the theory of living activity of various animals and from the point of view of practical medicine. This supports the old observations of Andjus on overcooled rats [1]. Now we know that a severe minimum of metabolism is retained up to the lowest temperatures of about −100 or −130°C [11].…”

Section: The Last Reserve For Saving a Homoeothermic Organism From Coldsupporting

confidence: 89%

“…This is associated with the fact that a high temperature disrupts the tissues, whereas low temperature, to the contrary, favors the conservation of the tissue structure. According to the old data of Andjus [1], a rat frozen at 0 to −1°C revived for a short time if its heart was rewarmed by a special thermode, and thus its circulation was partially restored. However, rewarming a man at a very deep cooling is very dangerous since the distribution of temperature ields may appear unfavorable for the most important organs of a living organism: brain and heart.…”

Section: Introductionmentioning

confidence: 99%

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Resuscitation of Overcooled Mammals without Rewarming

Ivanov¹

2017

Resuscitation Aspects

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Cold is a deadly danger for man. If the temperature of the surrounding air is +1°C, it is death for a naked man, owing to the arrest of respiration at the body temperature 25-28°C. After the heart is arrested, the death occurs at 23-24°C. Our aim was to prolong life at an absolutely deadly body temperature. This problem is important nowadays owing to a lot of sea catastrophes, the investigations in Arctic and Antarctic areas, and so on.

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Section: The Last Reserve For Saving a Homoeothermic Organism From Coldsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Resuscitation of Overcooled Mammals without Rewarming

Ivanov¹

2017

Resuscitation Aspects

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“…Smith, 1954, 1955;Andjus and Lovelock, 19.55;Goldzveig and Smith, 1956n). Andjus also found that rats would survive supercooling to several degrees below zero, but not partial freezing, when treated by the methods then in use (Andjus, 1955). I t was a particular pleasure to learn three years ago in Washington, D. C., that Niazi and Lewis, working independently and using entirely different methods had resuscitated ice-cold and inanimate rats and also monkeys that had been cooled to temperatures only a little above zero and well below the previously accepted lethal limit at which breathing and heartbeats cease.…”

mentioning

confidence: 82%

Viability of Supercooled and Frozen Mammals

Smith¹

1959

Annals of the New York Academy of Sciences

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“…As a result of difficulties in the clinical application of the technique, a large number of research labs have explored the safe period of circulatory arrest and pathological changes resulting from hypothermia. 116 Many of the early studies of hypothermia were done in smaller animals, such as rats 16 and rabbits. 17 However, most of the investigations in the last 15 years have used cats and dogs.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural Alterations in the Dog Brain After Profound Hypothermia Induced by Extracorporeal Circuit

Harris

Robertson

1974

Stroke

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Ullraslruclural Alterations in the Dog Brain After Profound Hypothermia Induced by Extracorporeal Circuit• This study has demonstrated that hypothermia with or without circulatory arrest produced ultrastructural alterations in the dog brain. Fluid accumulation in the perivascular area and in the neuropil persists for at least seven days. Neurons in all areas of the brain studied are quite resistant to fluid alterations. Minimal changes occurring in neurons appear to be reversible from these studies with no neuronal necrosis, even with cooling to 10°C. Endothelial cells and oligodendrocytes exhibit essentially normal morphology in all experimental groups. Astrocytes and their processes undergo the most severe alterations, with cellular changes greater in dogs subjected to 60 minutes than to 30 minutes of cardiac arrest, and progressive degrees of damage occurring with increases in postpumping time prior to sacrifice. Our studies indicate cytological damage increases for longer periods posthypothermia than earlier reports which noted a resolution at 72 hours of the edema observed at 24 hours. We have demonstrated with the electron microscope (EM) that edema persists for at least seven days.The application of new developments in the pumping technique such as improved filtering of microemboli may reduce the pathological alterations described in this study and aid the clinical management of patients subjected to hypothermia.

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Suspended animation in cooled, supercooled and frozen rats

Cited by 50 publications

References 7 publications

Resuscitation of Overcooled Mammals without Rewarming

Resuscitation of Overcooled Mammals without Rewarming

Viability of Supercooled and Frozen Mammals

Ultrastructural Alterations in the Dog Brain After Profound Hypothermia Induced by Extracorporeal Circuit

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