Suspended CNT-Based FET sensor for ultrasensitive and label-free detection of DNA hybridization

Sun, Yang; Peng, Zhong; Li, Huamin; Wang, Ziqun; Mu, Yanqi; Zhang, Guang-Ping; Chen, Shuo; Liu, Siyu; Wang, Gongtang; Liu, Chundong; Sun, Lianfeng; Man, Baoyuan; Yang, Cheng

doi:10.1016/j.bios.2019.04.054

Cited by 50 publications

(32 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 In this paper we have developed our methodology further to demonstrate how DNA strand detection using LD spectroscopy can provide a viable alternative to more established read-out methodologies. [2][3][4][5] Our approach, using two M13 probes in a sandwich assay, shows the versatility and sensitivity of the LD technique in detecting DNA target strands selectively and rapidly. It also showcases the ready use of a naturally occurring nanoparticle 15 as a cheap alternative to the myriad of synthetic nanoparticles currently used within various DNA technologies.…”

Section: Discussionmentioning

confidence: 99%

Combining bacteriophage engineering and linear dichroism spectroscopy to produce a DNA hybridisation assay

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Combining bacteriophage engineering and linear dichroism spectroscopy to produce a DNA hybridisation assay

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Stepping gating of ion channels on the nanoelectrode via DNA hybridization, carbon dot stabilized silver–lipid nanohybrids, and carbon nanotube-based FET shows label-free DNA detection. 68 − 70 …”

Section: Diagnostic Approaches To Covid-19mentioning

confidence: 99%

Current and Perspective Diagnostic Techniques for COVID-19

et al. 2020

View full text Add to dashboard Cite

Since late December 2019, the coronavirus pandemic (COVID-19; previously known as 2019-nCoV) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been surging rapidly around the world. With more than 1,700,000 confirmed cases, the world faces an unprecedented economic, social, and health impact. The early, rapid, sensitive, and accurate diagnosis of viral infection provides rapid responses for public health surveillance, prevention, and control of contagious diffusion. More than 30% of the confirmed cases are asymptomatic, and the high false-negative rate (FNR) of a single assay requires the development of novel diagnostic techniques, combinative approaches, sampling from different locations, and consecutive detection. The recurrence of discharged patients indicates the need for long-term monitoring and tracking. Diagnostic and therapeutic methods are evolving with a deeper understanding of virus pathology and the potential for relapse. In this Review, a comprehensive summary and comparison of different SARS-CoV-2 diagnostic methods are provided for researchers and clinicians to develop appropriate strategies for the timely and effective detection of SARS-CoV-2. The survey of current biosensors and diagnostic devices for viral nucleic acids, proteins, and particles and chest tomography will provide insight into the development of novel perspective techniques for the diagnosis of COVID-19.

show abstract

“…DNA was adopted to study the performance of such a sensor for biological monitoring. PBASE acting as a bridge between the graphene and probe DNA was introduced because its pyrene group can form π–π stacking with graphene, and its succinimide portion can be conjugated with probe DNA modified by –NH 2 (Figure 8a,b) [36,37]. To obtain the limit of detection of such a sensor to DNA, FC-DNA at different concentrations was used to hybridize with probe DNA by base complementary pairing, as shown in Figure 8c.…”

Section: Resultsmentioning

confidence: 99%

Preparation of Graphene/ITO Nanorod Metamaterial/U-Bent-Annealing Fiber Sensor and DNA Biomolecule Detection

Yang

et al. 2019

Nanomaterials

Self Cite

View full text Add to dashboard Cite

In this paper, a graphene/ITO nanorod metamaterial/U-bent-annealing (Gr/ITO-NM/U-bent-A)-based U-bent optical fiber local surface plasmon resonance (LSPR) sensor is presented and demonstrated for DNA detection. The proposed sensor, compared with other conventional sensors, exhibits higher sensitivity, lower cost, as well as better biological affinity and oxidize resistance. Besides, it has a structure of an original Indium Tin Oxides (ITO) nanocolumn array coated with graphene, allowing the sensor to exert significant bulk plasmon resonance effect. Moreover, for its discontinuous structure, a larger specific surface area is created to accommodate more biomolecules, thus maximizing the biological properties. The fabricated sensors exhibit great performance (690.7 nm/RIU) in alcohol solution testing. Furthermore, it also exhibits an excellent linear response (R2 = 0.998) to the target DNA with respective concentrations from 0.1 to 100 nM suggesting the promising medical applications of such sensors.

show abstract

Suspended CNT-Based FET sensor for ultrasensitive and label-free detection of DNA hybridization

Cited by 50 publications

References 27 publications

Combining bacteriophage engineering and linear dichroism spectroscopy to produce a DNA hybridisation assay

Combining bacteriophage engineering and linear dichroism spectroscopy to produce a DNA hybridisation assay

Current and Perspective Diagnostic Techniques for COVID-19

Preparation of Graphene/ITO Nanorod Metamaterial/U-Bent-Annealing Fiber Sensor and DNA Biomolecule Detection

Contact Info

Product

Resources

About