High loads of suspended sediments in rivers are known to cause detrimental effects to potable water sources, river water quality, irrigation activities, and dam or reservoir operations. For this reason, the study of suspended sediment load (SSL) prediction is important for monitoring and damage mitigation purposes. The present study tests and develops machine learning (ML) models, based on the support vector machine (SVM), artificial neural network (ANN) and long short-term memory (LSTM) algorithms, to predict SSL based on 11 different river data sets comprising of streamflow (SF) and SSL data obtained from the Malaysian Department of Irrigation and Drainage. The main objective of the present study is to propose a single model that is capable of accurately predicting SSLs for any river data set within Peninsular Malaysia. The ANN3 model, based on the ANN algorithm and input scenario 3 (inputs consisting of current-day SF, previous-day SF, and previous-day SSL), is determined as the best model in the present study as it produced the best predictive performance for 5 out of 11 of the tested data sets and obtained the highest average RM with a score of 2.64 when compared to the other tested models, indicating that it has the highest reliability to produce relatively high-accuracy SSL predictions for different data sets. Therefore, the ANN3 model is proposed as a universal model for the prediction of SSL within Peninsular Malaysia.