Introduction. Suspension trauma, also referred to as a harness-induced pathology or suspension syndrome, occurs when an individual is suspended motionless in a harness. Potentially fatal outcomes of such a condition consist in venous pooling, cerebral hypoperfusion, and rhabdomyolysis.Objective. To review literature sources on the key mechanisms of suspension injury and potential methods for improving the safety of people at risk.Results. This condition, recognized since the 1970s, affects individuals involved in activities requiring harness use, such as climbing and industrial work. Recent studies have emphasized the need for immediate horizontal positioning during rescue to restore blood flow and prevent complications. Proper management of hyperkalemia and rhabdomyolysis has become a crucial focus in treatment protocols. Additionally, recognition of the role of the Bezold–Jarisch reflex in cardiovascular collapse highlights the importance of comprehensive rescue strategies. Advances in harness design are also noted as significant preventive measures.Discussion. The findings indicate that while early management strategies focused on preventing sudden blood return to the heart by maintaining an upright position, more recent insights emphasize the importance of prompt horizontal repositioning. The role of neurocardiogenic factors, such as the Bezold–Jarisch reflex and the influence of rhabdomyolysis-related hyperkalemia, on outcomes has been recognized. This shift reflects an increased awareness of comprehensive rescue protocols that might mitigate risks associated with reflow syndrome and cardiovascular instability.Conclusions. The progress in understanding suspension injury has significantly improved prevention and treatment protocols. Immediate adjustment of the victim to a horizontal position, proper treatment of complications (for example, hyperkalemia), and improved design of safety systems — all play a key role in minimizing deaths. Further studies should be aimed at investigating the main pathogenetic mechanisms of suspension syndrome and development of advanced rescue methods for improving the safety of people at risk.