“…Among bioceramics, hydroxyapatite (HA) is the most similar material to the mineral component of bones; it exhibits biocompatibility, osteoconductivity and bioactive behaviour, being able to bond to the bone directly. For these reasons, HA has been employed in powder form or granules in many oral, maxillofacial and orthopaedic applications [5,6], and to realize bioactive coatings on metal implants in order to provide them with an osteophilic surface, which promotes a stronger bone-to-implant bonding [7,8]. Unfortunately, although HA is bioactive, its reactivity with existing bone tissue is low.…”