Suspensions of manganese-grafted nanodiamonds: Preparation, NMR, and MRI study

Panich, A. M.; Salti, Moti; Aleksenskii, A. E.; Kulvelis, Yu. V.; Chizhikova, Anastasia; Vul, A. Ya.; Shames, Alexander I.

doi:10.1016/j.diamond.2022.109591

Cited by 12 publications

(12 citation statements)

References 35 publications

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“…In spite of some risks that over accumulation of Mn 2+ ions could pose, they are still considered promising as there exists a possibility of employing nanocarriers to retain these ions until release to target specific targets. In this regard, Panich et al recently examined the properties of Mngrafted DND particles by measuring factors consisting of relaxivities, rates of proton relaxation along with the MRI images incorporated in 16 aqueous and saline suspensions of these NDs mimicking the biological environment of the human body [236]. The relaxation rates were found to be linearly related to Mn ion concentration.…”

Section: Bioimaging and Cancer Diagnosismentioning

confidence: 99%

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

Dey,

Ghosh,

Sanyal

et al. 2024

Biomed. Mater.

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In terms of biomedical tools, nanodiamond (ND) is a more recent innovation. Their size ranged from 4 to 100 nm. ND is produced via a variety of methods and is known for its physical toughness, durability, and chemical stability. The study revealed that surface modifications and functionalization have a significant influence on the optical and electrical properties of the nanomaterial. ND's surface functional groups have applications in a variety of domains, including drug administration, gene delivery, immunotherapy for cancer treatment, and bio-imaging to diagnose cancer. The biocompatibility of a material is critical for in vivo and in vitro interventions. This review focuses on recent advances in the methods of ND synthesis and ND-assisted drug delivery, moving through studies in cellular and animal models and bio-imaging for other biomedical applications. Furthermore, the prognosis of its clinical translation is being studied.

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Section: Bioimaging and Cancer Diagnosismentioning

confidence: 99%

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

Dey,

Ghosh,

Sanyal

et al. 2024

Biomed. Mater.

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“…Panich et al successfully prepared suspensions of Gd-DND at different concentrations and their suspensions showed high proton relaxivity. Such suspensions are promising as MRI contrast agents, which can shorten the spin-lattice (T 1 ) and spin-spin (T 2 ) relaxation times of water protons and increase the signal intensity of T 1 - and T 2 -weighted MRI images [ 65 ]. To maintain the stability of the Gd-DND complex in saline and to avoid its further coagulation in blood, the Gd-DND particles were coated with a polyvinylpyrrolidone (PVP) protective shell, and the obtained PVP-Gd-DND contrast agent provided a higher T 1 -weighted hyperintense signal [ 61 ].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…The high relaxivity and low toxicity of manganese compounds relative to gadolinium (III) ions allow their use as MRI contrast agents. Panich et al recently prepared high-purity 4–5 nm DND powders, and the reaction of aqueous suspensions of DNDs with aqueous manganese sulfate solutions allowed direct grafting of Mn 2+ ions onto the surface of DNDs [ 65 , 66 ]. Similarly performing PVP coverage avoids possible coagulation of the particles in the blood.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

Wang,

Sang,

Zou

et al. 2023

Molecules

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Nanodiamonds (NDs) are emerging as a promising candidate for multimodal bioimaging on account of their optical and spectroscopic properties. NDs are extensively utilized for bioimaging probes due to their defects and admixtures in their crystal lattice. There are many optically active defects presented in NDs called color centers, which are highly photostable, extremely sensitive to bioimaging, and capable of electron leap in the forbidden band; further, they absorb or emit light when leaping, enabling the nanodiamond to fluoresce. Fluorescent imaging plays a significant role in bioscience research, but traditional fluorescent dyes have some drawbacks in physical, optical and toxicity aspects. As a novel fluorescent labeling tool, NDs have become the focus of research in the field of biomarkers in recent years because of their various irreplaceable advantages. This review primarily focuses on the recent application progress of nanodiamonds in the field of bioimaging. In this paper, we will summarize the progress of ND research from the following aspects (including fluorescence imaging, Raman imaging, X-ray imaging, magnetic modulation fluorescence imaging, magnetic resonance imaging, cathodoluminescence imaging, and optical coherence tomography imaging) and expect to supply an outlook contribution for future nanodiamond exploration in bioimaging.

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“…Recently, novel CM based on the detonation of nanodiamond (DND) particles with grafted paramagnetic metal cations have been developed [ 31 , 32 , 33 , 34 ]. Gd-grafted DND exhibit superior relaxivity properties, exceeding most of those known in the literature [ 31 ].…”

Section: Contrast Mediamentioning

confidence: 99%

Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy)

Панова¹,

Татиколов

2023

Pharmaceuticals

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The use of conventional contrast media for diagnostic purposes (in particular, Gd-containing and iodinated agents) causes a large number of complications, the most common of which is contrast-induced nephropathy. It has been shown that after exposure to contrast agents, oxidative stress often occurs in patients, especially in people suffering from various diseases. Antioxidants in the human body can diminish the pathological consequences of the use of contrast media by suppressing oxidative stress. This review considers the research studies on the role of antioxidants in preventing the negative consequences of the use of contrast agents in diagnostics (mainly contrast-induced nephropathy) and the clinical trials of different antioxidant drugs against contrast-induced nephropathy. Composite antioxidant/contrast systems as theranostic agents are also considered.

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Suspensions of manganese-grafted nanodiamonds: Preparation, NMR, and MRI study

Cited by 12 publications

References 35 publications

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy)

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