This study explores the impact of AIS on improving the Agility and sustainability of small businesses in the context of Industry 5.0. This chapter highlights how AIS enables real-time data tracking, cost management, and resource optimization, enhancing decision-making and operational efficiency to promote SMEs' Agility and sustainability. Through the integration of AIS, small businesses can enhance their ability to effectively manage supplier data, monitor sustainability metrics, and optimize supply chain processes. The study reveals that AIS greatly enhances small business agility by facilitating rapid responses to market changes and optimizing resource utilization. Additionally, it promotes sustainability by reducing waste and improving resource management efficiency. The practical implications of this research encompass improved decision-making, effective cost control, and increased employee engagement. Theoretical contributions emphasize the importance of AIS in achieving strategic and sustainable business outcomes in Industry 5.0, aligning with dynamic capabilities