The development of Industry 4.0 has a significant impact not only on production processes but also on the functioning and future of regions. It is crucial to understand the phenomena taking place in the social and economic space both from the cognitive and practical point of view. The article is based on research which investigates the prospect of communes in the context of Industry 4.0 development. The aim of the article is to show possible consequences of the development of Industry 4.0 from the local perspective. The basic assumption is a positive impact of entrepreneurship on ensuring sustainable regional development. The model adopted is built on a resource-based view and includes both invariable, external and independent resources such as location, as well as those which are variable in the longer term, such as human and social capital. To verify most of the hypotheses, a linear regression model has been created. The results of the research show that there is a strong correlation between human capital, social capital, proximity of an agglomeration and tourist attractiveness of a region, and regional development operationalised by the number of enterprises. The article presents possible directions of changes in the profiles of local units, as well as the conditions which have to be met in order to enable such a transformation.