Sustainability of green solvents – review and perspective

Hessel, Volker; Tran, Nam Nghiep; Asrami, Mahdieh Razi; Tran, Quy Don; Nguyen, Van Duc Long; Escribà‐Gelonch, Marc; Osorio-Tejada, José Luis; Linke, Steffen; Sundmacher, Kai

doi:10.1039/d1gc03662a

Cited by 173 publications

(94 citation statements)

References 256 publications

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“…According to the concept of green chemistry [ 43 , 44 ], in order to minimize the negative influence of the chemical industry on the environment, there is a need to reduce or even eliminate the usage of hazardous chemical substances including solvents, which should be replaced with environmentally friendly green solvents [ 45 , 46 ]. Apart from ionic liquids (IL) and supercritical fluids (SCF), the concept of green solvents also includes deep eutectic solvents (DES), which are mixtures of two or more individual components with a melting point of the mixture lower than the ones of its components [ 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Jeliński¹,

Cysewski²

2022

IJMS

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Solubility of active pharmaceutical ingredients is an important aspect of drug processing and formulation. Although caffeine was a subject of many studies aiming to quantify saturated solutions, many applied solvents suffer from not being environmentally friendly. This work fills this gap by presenting the results of solubility measurements in choline chloride natural deep eutectic solvents, ccNADES, comprising one of seven of the following polyalcohols: glycerol, sorbitol, xylitol, glucose, sucrose, maltose and fructose. The ratio of ccNADES components was optimized for maximizing caffeine solubility at room temperature. Additionally, temperature dependent solubility was measured for the first four systems exhibiting the highest solubility potential, both in their neat forms and in mixtures with water. Results were used for intermolecular interactions assessments using the COSMO-RS-DARE approach, which led to a perfect match between experimental and computed solubility values. An important methodological discussion was provided for an appropriate definition of the systems. Surprising linear trends were observed between the values of fitting parameters and water-ccNADES composition. In addition, comments on selection of the values of the fusion thermodynamic parameters were provided, which led to the conclusion that COSMO-RS-DARE solubility computations can effectively compensate for the inaccuracies of these important physicochemical properties.

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Section: Introductionmentioning

confidence: 99%

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Jeliński¹,

Cysewski²

2022

IJMS

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“…In many organic processes, the solvent plays a crucial role in the overall performance. It is the major reaction component [ 37 ], representing a high economic cost for the industry and a relevant global issue for public health [ 38 , 39 ]. Unfortunately, solvent removal from a process is not a trivial task as it often seriously affects the reaction outcome [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

et al. 2022

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The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin, and N-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.

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“…The idea of creating a pollution-free environment has urged the chemical industries to perform reactions under greener conditions. [1][2][3] The utilization of an aqueous medium for performing chemical reactions has several advantages in terms of safety, environmental benignity, and cost, which has resulted in the development of several organic transformations "onwater". [4][5][6][7][8][9][10][11][12][13][14][15][16][17] However, the dehydrative substitution reaction in an aqueous medium is a highly challenging operation.…”

Section: Introductionmentioning

confidence: 99%

Dehydrative Substitution Reaction in Water for the Preparation of Unsymmetrically Substituted Triarylmethanes: Synthesis, Aggregation‐Enhanced Emission, and Mechanofluorochromism

et al. 2022

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Water as a reaction media in chemical transformations has several advantages in terms of safety and non-toxicity. However, dehydrative substitution reaction in water is a highly challenging operation. In this paper, we have reported a sulfamic acid-mediated dehydrative substitution reaction of benzofuryl alcohols with several nucleophiles in water towards the scalable, easily isolable, synthesis of unsymmetrically substituted triarylmethanes (TRAMs) in good to excellent yields (up to 92 %). Moreover, we have demonstrated that rationally designed propellor-shaped triarylmethanes promote aggregation-induced emission (AIE) through restricted intramolecular rotation with irreversible mechanoflurochromic property.

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Sustainability of green solvents – review and perspective

Abstract: Solvents define pivotal properties for chemical processing and chemical reactions, and can be as much game-changing as catalysts are. A solvent can be the key to a good chemical process,...

Cited by 173 publications

References 256 publications

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

Dehydrative Substitution Reaction in Water for the Preparation of Unsymmetrically Substituted Triarylmethanes: Synthesis, Aggregation‐Enhanced Emission, and Mechanofluorochromism

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