Sustainable development and sustainability encompass a strong focus on the advancement of sustainable societies, social sustainability, and overall well-being of people both now and in the future. These goals also highlight sustainable social/society–environment relationships and interfaces to promote sustainable development of both people and the planet. The promotion of social sustainability requires leadership, management, and assessment by organizations and people. This study explored social sustainability handprints from the perspective of handprint and life cycle thinking and approaches using qualitative research approaches. It addressed a clear gap in research and aimed at exploring, discovering, analyzing and synthetizing the main implications of these frameworks for the creation and assessment of the social sustainability handprint development. It was recognized that there are multiple ways to create social sustainability handprints, such as positive changes, actions, innovations, and impacts. The same applies to assessments that can be based on, for example, handprint and life cycle thinking and approaches, sustainability management, assessment and indicators, and sustainability science. The findings highlight the broadness and diversity of approaches, opportunities, and possibilities related to both the creation and assessment of social sustainability handprints. Additionally, they suggest that particular focus is needed, for example, on comprehensive approaches that take into account specific contexts, locations, cultures, scales, conditions, characteristics, perspectives, and stakeholders.