This paper develops an empirical methodology to consistently compare alternative sustainability paradigms (weak sustainability (WS), strong sustainability (SS), a-growth (AG), and de-growth (DG)) and different assessment approaches (LCA, CBA, and MCA) within alternative relationship frameworks (economic general equilibrium (EGE) and ecosystem services (ESS)). The goal is to suggest different environmental interventions (e.g., projects vs. policies) for environmental management at national, regional, or local levels. The top-down methodology is then applied to 30 interdependent industries in Italy for three pollutants and four resources during two periods. The industries were prioritized in terms of interventions to be taken to diminish pollution damage and resource depletion, whereas sustainability paradigms were compared in terms of their likelihood (i.e., WS > AG = DG > SS), robustness (i.e., AG > SS > DG > WS), effectiveness (i.e., SS > AG > DG > WS), and feasibility (i.e., SS > DG > WS > AG). Proper assessment approaches for projects are finally identified for situations when policies are infeasible (e.g., LCA in WS and SS, MCA in DG and SS within ESS, CBA in WS, and AG within EGE), by suggesting MCA in WS within ESS once ecological services are linked to sustainability criteria.