Sustainable and Antioxidant Lignin–Polyester Copolymers and Nanofibers for Potential Healthcare Applications

Kai, Dan; Zhang, Kangyi; Lu, Jiang; Wong, Hua Zhong; Liu, Yupeng; Zhang, Zheng; Loh, Xian Jun

doi:10.1021/acssuschemeng.7b00850

Cited by 162 publications

(104 citation statements)

References 55 publications

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“…The hydrophilicity feature of any material for biomedical applications is a crucial parameter, as it can affect cell adhesion and growth on its surface [43]. The surface hydrophilicity of the nanofibrous membranes was characterized by contact angle measurements.…”

Section: Resultsmentioning

confidence: 99%

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

Locilento

Mercante

André

et al. 2019

Journal of Nanomaterials

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The development of nanofibrous membranes with tunable wettability, degradation, and biocompatibility is highly keen for biomedical applications, including drug delivery and wound dressing. In this study, biocompatible and biodegradable nanofibrous membranes with antioxidant properties were successfully prepared by the electrospinning technique. The membranes were developed using polylactic acid (PLA) and polyethylene oxide (PEO) as the matrix, with the addition of grape seed extract (GSE), a rich source of natural antioxidants. The nanofibrous membranes were thoroughly characterized both from the materials and from the biocompatibility point of view. PLA and PLA/PEO nanofibers showed high encapsulation efficiency, close to 90%, while the encapsulated GSE retained its antioxidant capacity in the membranes. In vitro release studies showed that GSE diffuses from PLA/GSE and PLA/PEO/GSE membranes in a Fickian diffusion manner, whose experimental data were well fitted using the Korsmeyer-Peppas model. Furthermore, a higher controlled release of GSE was observed for the PLA/PEO/GSE membrane. Moreover, culturing experiments with human foreskin fibroblast (HFF1) cells demonstrated that all samples are biocompatible and showed that the GSE-loaded PLA/PEO nanofibrous membranes support better cell attachment and proliferation compared to the PLA/GSE nanofibrous membranes, owing to the superior hydrophilicity. In summary, the results suggested that the GSE-loaded membranes are a promising topical drug delivery system and have a great potential for wound dressing applications.

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Section: Resultsmentioning

confidence: 99%

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

Locilento

Mercante

André

et al. 2019

Journal of Nanomaterials

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“…PS‐ and PLA‐containing copolymers are emerging biomaterials due to their excellent biocompatibility and/or biodegradability . In this study, the proof of concept of using the newly developed Janus star‐like copolymer (PLLA) 8 ‐ b‐ (PS) 8 as therapeutic nanocarriers is also demonstrated.…”

Section: Methodsmentioning

confidence: 94%

Precise Synthesis of PS‐PLA Janus Star‐Like Copolymer

Fan

Win

et al. 2018

Macromol. Rapid Commun.

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In this work, an efficient strategy is designed for the precise synthesis of novel Janus star-like copolymer (polystyrene) -b-(poly(l-lactide)) , (PLLA) -b-(PS) , consisting of two types of chemically distinct polymer arms, PS and PLLA, in an asymmetric structure. During the synthesis, PLLA hemisphere carrying protected hydroxyl groups at the focal point was first synthesized via a combined reactions of esterification, light-induced "Click" chemistry, and ring opening polymerization (ROP) using a specially designed dendron as initiator. After removing the protecting moiety, the terminal hydroxyl groups on the dendron segment is increased fourfold and further modified into bromopropionate-based macroinitiator through a two-step end group transformation reaction, followed by atom transfer radical polymerization (ATRP) of styrene to obtain the desired (PLLA) -b-(PS) Janus star-like copolymer. The versatility and efficiency of the designed synthetic strategy are demonstrated by the well-defined molecular characteristics and high yields of the targeted product. In addition to the controlled degradation behavior of the PLLA segments, the remaining bromide groups located at the distal end of PS arms could allow for further fabrication of diverse building blocks through consecutive ATRP of various monomers. This work signifies the first time for facile and precise synthesis of Janus star-like copolymer with unique biphasic structure and function control.

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“…Rheological Studies: DPPH assay is the general method to evaluated antioxidant activities. [18,24] Each sample (0.5 mL) was configured into different concentration gradients, and then mixed with 3.5 mL of DPPH radical solution. Absorbance at 517 nm was measured after 60 min in an incubator at 37 °C for three times.…”

Section: Methodsmentioning

confidence: 99%

Multifunctional pH‐Responsive Sprayable Hydrogel Based on Chitosan and Lignin‐Based Nanoparticles

Zhu

Lü

Dai

2018

Part & Part Syst Charact

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Multifunctional sprayable hydrogels are widely developed for daily chemical and biomedical application. However, adding functional components and active ingredients is difficult to achieve uniform distribution and controlled release. Here, a new kind of lignin‐based nanoparticles is prepared, which can give hydrogels more functions (anti‐ultraviolet and antioxidant properties) and promote the response of hydrogels to pH stimulus. The nanocomposite hydrogels are engineered using carboxymethyl chitosan (CS) and trans‐resveratrol‐loaded lignin‐based nanoparticles (LRNPs). The rheological, anti‐ultraviolet, and antioxidant properties of the sprayable hydrogel can be fine‐tuned by varying the ratio of lignin‐based nanoparticles. More importantly, the release behavior of the active ingredient can be flexibly controlled by adjusting the pH environment. This work provides a facile approach to fabricate a green and intelligent sprayable hydrogel amenable to a great potential in daily chemical and biomedical area.

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Sustainable and Antioxidant Lignin–Polyester Copolymers and Nanofibers for Potential Healthcare Applications

Cited by 162 publications

References 55 publications

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application

Precise Synthesis of PS‐PLA Janus Star‐Like Copolymer

Multifunctional pH‐Responsive Sprayable Hydrogel Based on Chitosan and Lignin‐Based Nanoparticles

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