Sustainable biosynthesis of curdlan from orange waste by using Alcaligenes faecalis: A systematically modeled approach

Mohsin, Ali; Sun, Jingru; Khan, Imran Mahmood; Hang, Haifeng; Tariq, Muhammad; Tian, Xiaohui; Ahmed, Waqas; Niazi, Sobia; Zhuang, Yingping; Chu, Ju; Mohsin, Muhammad; Salim-ur-Rehman, .; Guo, Meijin

doi:10.1016/j.carbpol.2018.10.047

Cited by 46 publications

(18 citation statements)

References 32 publications

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“…Then, the FTIR spectrum was recorded at room temperature, using 20 scans from 4000 to 400 cm -1 with a resolution of 4 cm -1 . Meanwhile, the FTIR spectra of homopolymers Levan, [154][155][156][157][158][159] Curdlan, [160][161][162][163][164][165] and Paenan [166,167] were extracted from the literature using Engauge Digitizer Version 10.10 software. The homopolymer spectra's average transmittances were normalized between 1 and 100, using LibreOffice Calc Version: 6.2.8.2.…”

Section: Methodsmentioning

confidence: 99%

Monte Carlo Assisted FTIR Spectroscopy: A Python Tool for the Determination of the Constituents in Blended Biopolymer Samples

Souza

Cunha

Pereira

et al. 2021

Macromolecular Symposia

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A massive number of biopolymers and complex polymer blends are being developed every day. One of the significant challenges related to these materials is their characterization. In more specific terms, estimating the composition of polymeric mixtures is a substantial challenge for the technologist, who must understand the nuances of the material's composition for its proper application. Thus, this work develops a Python code capable of handling the composition analysis using the FTIR spectra of some biopolymers found in the literature. Through the Monte Carlo method associated with the Mixture Rule, these spectra are combined, generating a myriad of signals referring to different compositions. These signals are compared with the one from the FTIR spectrum of the mixture, allowing the root-mean-square error (RMSE) calculation. Finally, minimizing the RMSE value leads to the final composition of the material, which is presented and saved in a text file.

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Section: Methodsmentioning

confidence: 99%

Monte Carlo Assisted FTIR Spectroscopy: A Python Tool for the Determination of the Constituents in Blended Biopolymer Samples

Souza

Cunha

Pereira

et al. 2021

Macromolecular Symposia

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“…Curdlan is produced by Alcaligenes faecalis, Rhizobium radiobacter, and Agrobacterium species in a nitrogen-limiting environment with glucose or sucrose as the carbon source [172][173][174][175]. Factors known to affect curdlan biosynthesis include the nitrogen source, the carbon source, oxygen supply, and pH [176][177][178][179].…”

Section: Curdlanmentioning

confidence: 99%

Biomedical Applications of Bacterial Exopolysaccharides: A Review

et al. 2021

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Bacterial exopolysaccharides (EPSs) are an essential group of compounds secreted by bacteria. These versatile EPSs are utilized individually or in combination with different materials for a broad range of biomedical field functions. The various applications can be explained by the vast number of derivatives with useful properties that can be controlled. This review offers insight on the current research trend of nine commonly used EPSs, their biosynthesis pathways, their characteristics, and the biomedical applications of these relevant bioproducts.

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“…By this technique, the dried orange peels yielded about 23.24 g/L of curdlan. The fermentation substrate showed significant effects on the development of curdlan and presented a novel engineered approach for the production of curdlan in an environment-friendly manner ( 49 ).…”

Section: Biosynthesis Of Curdlanmentioning

confidence: 99%

Therapeutic and Industrial Applications of Curdlan With Overview on Its Recent Patents

et al. 2021

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Curdlan is an exopolysaccharide, which is composed of glucose linked with β-(1,3)-glycosidic bond and is produced by bacteria, such as Alcaligenes spp., Agrobacterium spp., Paenibacillus spp., Rhizobium spp., Saccharomyces cerevisiae, Candida spp., and fungal sources like Aureobasidium pullulan, Poria cocos, etc. Curdlan has been utilized in the food and pharmaceutical industries for its prebiotic, viscosifying, and water-holding properties for decades. Recently, the usefulness of curdlan has been further explored by the pharmaceutical industry for its potential therapeutic applications. Curdlan has exhibited immunoregulatory and antitumor activity in preclinical settings. It was observed that curdlan can prevent the proliferation of malarial merozoites in vivo; therefore, it may be considered as a promising therapy for the treatment of end-stage malaria. In addition, curdlan has demonstrated potent antiviral effects against human immunodeficiency virus (HIV) and Aedes aegypti virus. It has been suggested that the virucidal properties of curdlans should be extended further for other deadly viruses, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2/COVID-19). The prebiotic property of curdlan would confer beneficial effects on the host by promoting the growth of healthy microbiota in the gut and consequently help to reduce gastrointestinal disorders. Therefore, curdlan can be employed in the manufacture of prebiotics for the management of various gastrointestinal dysbiosis problems. Studies on the mechanism of action of curdlan-induced suppression in microbial and tumor cells at the cellular and molecular levels would not only enhance our understanding regarding the therapeutic effectiveness of curdlan but also help in the discovery of new drugs and dietary supplements. The primary focus of this review is to highlight the therapeutic interventions of curdlan as an anticancer, anti-malaria, antiviral, and antibacterial agent in humans. In addition, our review provides the latest information about the chemistry and biosynthesis of curdlan and its applications for making novel dairy products, functional foods, and nutraceuticals and also details about the recent patents of curdlan and its derivatives.

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Sustainable biosynthesis of curdlan from orange waste by using Alcaligenes faecalis: A systematically modeled approach

Cited by 46 publications

References 32 publications

Monte Carlo Assisted FTIR Spectroscopy: A Python Tool for the Determination of the Constituents in Blended Biopolymer Samples

Monte Carlo Assisted FTIR Spectroscopy: A Python Tool for the Determination of the Constituents in Blended Biopolymer Samples

Biomedical Applications of Bacterial Exopolysaccharides: A Review

Therapeutic and Industrial Applications of Curdlan With Overview on Its Recent Patents

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