Sustainable biosynthesis of squalene from waste cooking oil by the yeast Yarrowia lipolytica

Wang, Shuhui; Sun, Xu; Han, Yuqing; Li, Zhuo; Lu, Xiaocong; Shi, Hongrui; Zhang, Cui-ying; Wong, Adison; Yu, Aiqun

doi:10.1016/j.mec.2024.e00240

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2024

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Cited by 3 publications

References 40 publications

(49 reference statements)

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Rhamnolipid production from waste cooking oil by a newly isolated thermo- and salt-tolerant Pseudomonas aeruginosa GH01

Gao,

Zhang,

Yuan

et al. 2024

World J Microbiol Biotechnol

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Rhamnolipid production from waste cooking oil by a newly isolated thermo- and salt-tolerant Pseudomonas aeruginosa GH01

Gao,

Zhang,

Yuan

et al. 2024

World J Microbiol Biotechnol

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Metabolic Engineering for Squalene Production: Advances and Perspectives

Chai,

Che,

et al. 2024

J. Agric. Food Chem.

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Squalene is a linear polyunsaturated triterpene which has multiple physiological functions including anticancer, antioxidant, and skin-care. It has been widely used in the food, medicine, and cosmetics sectors and also serves as a precursor of triterpenes and steroids. Recently, the production of squalene by microbial cell hosts has drawn much attention due to its sustainability, environmental friendliness, and great efficiency. In this review, we first introduce the recent developments in the production of squalene by employing microbial cell factories, especially yeasts. Next, we underscore the primary metabolic strategies, including the biosynthetic pathway engineering, precursor manipulation, cofactor engineering, and organelle engineering. In addition to traditional metabolic engineering strategies, we also discuss some prospective metabolic regulation approaches, including regulation of lipid synthesis, identifying and manipulating related transcription factors, dynamic regulation of the metabolic pathway, and secretion engineering of membrane-impermeable terpenoids. These approaches provide insights for further metabolic engineering of squalene and related terpenoids.

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Cost-Effective Production of Squalene Using Yarrowia Lipolytica Via Metabolic Engineering and Fermentation Engineering

Lin,

Chen,

Song

et al. 2024

Preprint

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Sustainable biosynthesis of squalene from waste cooking oil by the yeast Yarrowia lipolytica

Cited by 3 publications

References 40 publications

Rhamnolipid production from waste cooking oil by a newly isolated thermo- and salt-tolerant Pseudomonas aeruginosa GH01

Rhamnolipid production from waste cooking oil by a newly isolated thermo- and salt-tolerant Pseudomonas aeruginosa GH01

Metabolic Engineering for Squalene Production: Advances and Perspectives

Cost-Effective Production of Squalene Using Yarrowia Lipolytica Via Metabolic Engineering and Fermentation Engineering

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