The results of life-cycle assessments (LCAs) of concrete are highly dependent on the concrete design method. In this study, LCAs were conducted to evaluate the environmental impacts of the replacement of sand with furnace bottom-ash (FBA) in concrete. In the FBA-based concretes, sand was replaced with FBA at proportions of 0, 30, 50, 70, and 100 wt%. Two design methods were studied: (i) concrete with fixed slump ranges of 0-10 mm (CON-fix-SLUMP-0-10) and 30-60 mm (CON-fix-SLUMP-30-60); and (ii) concrete with fixed water/cement (W/C) ratios of 0.45 (CON-fix-W/C-0.45) and 0.55 (CON-fix-W/C-0.55). The ReCiPe2016 midpoint and single-score (six methodological options) methods were used to compare the environmental damage caused by the FBA-based concretes. A two-stage nested (hierarchical) analysis of variance (ANOVA) was used to simultaneously evaluate the results of six ReCiPe2016 methodologies. The ReCiPe2016 results indicate that replacing sand with FBA decreased the environmental impact of the concretes with fixed slump ranges and increased the environmental impact of the concretes with fixed W/C ratios. Therefore, using FBA as a partial sand replacement in concrete production is of debatable utility, as its impact highly depends on the concrete design method used.Sustainability 2019, 11, 4083 2 of 20 several industrial byproducts, such as FA, FBA, copper slag (CS), and quarry dust powder (QDP) [7][8][9]. Chowdhury et al. [7] studied the full replacement of sand with FA and FBA in road construction, and reported mixed results: climate change (e.g., CO 2 emissions) and environmental acidification were found to be lower for the byproducts, whereas the formation of particulate matter was found to be lower for the sand. Kua [8] performed a life-cycle assessment (LCA) of high-performance concrete in which sand had been partially (10 vol%) replaced with CS, and reported an increased climate change impact (e.g., increased CO 2 emissions) compared to that of conventional concrete. Lim et al. [9] studied the replacement of a high percentage of sand with QDP in lightweight foamed concrete, and reported a decrease in CO 2 emissions of up to 10%. This highlights that the effect of the partial or full substitution of sand in the production of concrete is not fully understood and requires additional research.Among all the possible industrial byproducts, the conversion of waste from coal-fired electricity production into an environmentally friendly byproduct for the production of concrete is a pressing issue for environmentally sustainable development in many countries [2]. For example, Zhang and Poon [10] considered the use of FBA, a waste byproduct from coal-fired electricity production, as an alternative to natural fine aggregates in byproduct-based concrete production to improve the concrete's environmental impact.The problem of producing concrete with a low environmental impact is also important for Israel. Concrete is a major building material in Israel [11], and furthermore, according to the Israel Electric Corporation Lt...