Sustainable Coated Nanostructures Based on Alginate and Electrospun Collagen Loaded with Antimicrobial Agents

Matei, Ecaterina; Gaidău, Carmen; Râpă, Maria; Stefan, Laura; Dițu, Lia-Mara; Predescu, Andra Mihaela; Stanca, Maria; Pantilimon, Cristian; Berechet, Mariana Daniela; Predescu, Cristian; Mosutiu, Anamaria

doi:10.3390/coatings11020121

Cited by 8 publications

(4 citation statements)

References 66 publications

(69 reference statements)

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“…In vitro, L929 murine fibroblasts cell assay confirmed a proper cytocompatibility for the collagen-alginate scaffold with antibacterial agents. Matei et al [97]…”

Section: Chitosan/ Alginatementioning

confidence: 99%

The Collagen-Based Scaffolds for Bone Regeneration: A Journey through Electrospun Composites Integrated with Organic and Inorganic Additives

et al. 2023

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Orthopedics has been identified as a major clinical medicine branch since the 18th century for musculoskeletal disease diagnosis and therapeutics. Along with technological progress, the surgical treatment of bone disorders became available in the 19th century, while its growth faced several obstacles due to a lack of proper biocompatible material and alternative structures. Therefore, tissue engineering has emerged as a key building block to overcome these challenges, providing the capability for bone growth, and fabricating scaffolds with enriched desirable cellular compatibility as well as mechanical properties. Among various structures, the electrospun layer has implied high porosity and fine pore sizes, and succeeded in cell growth and proliferation. Collagen nanofibers have represented a wide potential for mineralization, bone regeneration, and forming processes. Despite this, such scaffolds have accosted bone remodeling limitations due to inadequate osteoinductivity and mechanical strength. Hence, the tendency to fabricate efficient collagen-based nanofibrous layers enriched with organic and inorganic materials has been extensively declared. Embedding these materials leads to engineering a membrane with appropriate physical, degradability, and mechanical properties, as well as proper mineralization and biological activity required for better replicating the bone organ’s natural microenvironment. This paper highlighted a wide overview of the natural resources, electrospinning strategies, and collagen-based electrospun composites for bone regeneration. Accordingly, future prospects could be developed for generating novel 3D-scaffold formations, benefiting from organic and inorganic substances to boost the biological and mechanical properties, simultaneously.

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“…In vitro, L929 murine fibroblasts cell assay confirmed a proper cytocompatibility for the collagen-alginate scaffold with antibacterial agents. Matei et al [97]…”

Section: Chitosan/ Alginatementioning

confidence: 99%

The Collagen-Based Scaffolds for Bone Regeneration: A Journey through Electrospun Composites Integrated with Organic and Inorganic Additives

et al. 2023

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“…Starting from the SA film obtained with the internal gelation approach (Figure 2A,B), the FTIR spectrum showed characteristic and typical signals of alginate: a broad band at 3300 cm −1 ascribed to the stretching of hydrogen-bonded -OH groups; a band at 2926 cm −1 , attributed to -CH 2 symmetric and asymmetric vibration; and the alkyl groups at 2857 cm −1 [38][39][40][41]. The bands at 1595 and 1406 cm −1 can be attributed to the symmetric and asymmetric vibrations of the carboxylate moieties (COO − ).…”

Section: Uv-vis and Atr-ftir Measurementsmentioning

confidence: 99%

Realizing Eco-Friendly Water-Resistant Sodium-Alginate-Based Films Blended with a Polyphenolic Aqueous Extract from Grape Pomace Waste for Potential Food Packaging Applications

Gubitosa,

Rizzi,

Marasciulo

et al. 2023

IJMS

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Water-resistant and environmentally friendly sodium-alginate-based films have been investigated to develop functional materials to extend the food’s shelf-life. A water-stable alginate-based film was prepared, employing both the internal and external gelation approach in the presence of CaCl2. To apply this film to food packaging and thus preserve food quality, the aim of this work is to perform a chemical and physical characterization of the proposed materials, evidencing the main features and stability under different work conditions. Water contact angle measurements showed a value of 65°, suggesting an important reduced hydrophilic character of the obtained alginate films due to the novel CaCl2-induced compacted polymer network. The film’s stability was thus checked through swelling measurements in water after varying pH, temperature, and ionic strength. The film was stable at high temperatures and not pH-responsive. Only highly concentrated salt-based solutions negatively affected the proposed packaging, causing a large swelling. Furthermore, a water-based polyphenolic extract from grape (Vitis vinifera L.) pomace waste was embedded inside the films in different amounts in order to confer additional properties. The extract’s polyphenolic content (evaluated from HPLC/MS-MS measurements) endowed the films’ UV-light screening and enhanced antioxidant properties. These important findings suggest the additional potential role of these films in protecting food from light deterioration. The stability of these hybrid films was also checked by observation, as the polyphenols’ presence did not largely alter the alginate network that occurred yet was water-resistant under the described work conditions.

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“…The efficiency of gelatin-based nanofibers for wound healing stimulation was previously evaluated through in vitro and in vivo tests and correlated with gelatin structural properties, which can be preserved through electrospinning [34,36].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Gamma Radiation on Different Gelatin Nanofibers and Gelatins

Gaidau,

Râpă,

Ionita

et al. 2024

Gels

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Gelatin nanofibers are known as wound-healing biomaterials due to their high biocompatible, biodegradable, and non-antigenic properties compared to synthetic-polymer-fabricated nanofibers. The influence of gamma radiation doses on the structure of gelatin nanofiber dressings compared to gelatin of their origin is little known, although it is very important for the production of stable bioactive products. Different-origin gelatins were extracted from bovine and donkey hides, rabbit skins, and fish scales and used for fabrication of nanofibers through electrospinning of gelatin solutions in acetic acid. Nanofibers with sizes ranging from 73.50 nm to 230.46 nm were successfully prepared, thus showing the potential of different-origin gelatin by-products valorization as a lower-cost alternative to native collagen. The gelatin nanofibers together with their origin gelatins were treated with 10, 20, and 25 kGy gamma radiation doses and investigated for their structural stability through chemiluminescence and FTIR spectroscopy. Chemiluminescence analysis showed a stable behavior of gelatin nanofibers and gelatins up to 200 °C and increased chemiluminescent emission intensities for nanofibers treated with gamma radiation, at temperatures above 200 °C, compared to irradiated gelatins and non-irradiated nanofibers and gelatins. The electron paramagnetic (EPR) signals of DMPO adduct allowed for the identification of long-life HO● radicals only for bovine and donkey gelatin nanofibers treated with a 20 kGy gamma radiation dose. Microbial contamination with aerobic microorganisms, yeasts, filamentous fungi, Staphylococcus aureus, Escherichia coli, and Candida albicans of gelatin nanofibers treated with 10 kGy gamma radiation was under the limits required for pharmaceutical and topic formulations. Minor shifts of FTIR bands were observed at irradiation, indicating the preservation of secondary structure and stable properties of different-origin gelatin nanofibers.

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Sustainable Coated Nanostructures Based on Alginate and Electrospun Collagen Loaded with Antimicrobial Agents

Cited by 8 publications

References 66 publications

The Collagen-Based Scaffolds for Bone Regeneration: A Journey through Electrospun Composites Integrated with Organic and Inorganic Additives

The Collagen-Based Scaffolds for Bone Regeneration: A Journey through Electrospun Composites Integrated with Organic and Inorganic Additives

Realizing Eco-Friendly Water-Resistant Sodium-Alginate-Based Films Blended with a Polyphenolic Aqueous Extract from Grape Pomace Waste for Potential Food Packaging Applications

The Influence of Gamma Radiation on Different Gelatin Nanofibers and Gelatins

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