This chapter explores the intersection of blockchain technology and knowledge sharing systems, examining how distributed ledger technology can revolutionize collaboration and information exchange across various domains. We investigate the potential of blockchain to create secure, transparent, and decentralized platforms for knowledge management, addressing current challenges in traditional systems such as data silos, lack of trust, and inefficient information flow. Through a comprehensive literature review, methodology discussion, and analysis of relevant case studies and experimental research, we demonstrate the transformative impact of blockchain on knowledge sharing practices. The chapter also delves into future trends and potential applications, providing insights into the evolving landscape of blockchain-based collaboration systems.