This mixed-methods study examines how political leaders mobilize collective intentionality during the COVID-19 pandemic in nine US States, and how collective intentionality differs across republican and democratic administrations. The results of our qualitative and quantitative analyses show that i) political leaders establish collective intentionality by emphasizing unity, vulnerability, action, and community boundaries; ii) political leaders’ call to collective action clashes with the inaction required by health guidelines; iii) social inequalities received little attention across all states compared to other themes; iv) collective intentionality in democratic administrations is linked to individuals’ agency and actions, suggesting a bottom-up approach. Conversely, in republican administrations individuals’ contributions are downplayed compared to work and state-level action, indicating a top-down approach. This study demonstrates the theoretical and empirical value of collective intentionality in sociological research, and contributes to a better understanding of leadership and prosociality in times of crisis.