Sustainable functionalization and modification of materials via multicomponent reactions in water

Javanbakht, Siamak; Nasiriani, Tahereh; Farhid, Hassan; Nazeri, Mohammad Taghi; Shaabani, Ahmad

doi:10.1007/s11705-022-2150-6

Cited by 9 publications

(2 citation statements)

References 153 publications

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“…Click protein chemistry has given rise to a myriad of highly interesting developments in the field of medicine and has significantly impacted the synthesis of structurally diverse molecules through shorter, stereoselective, and efficient synthetic routes. In continuation of our previous review articles on modified/functionalized materials via multicomponent reactions strategy as "click" reactions (Afshari and Shaabani, 2018;Javanbakht and Shaabani, 2019;Javanbakht et al, 2022), herein, an attempt has been made to review the medicinal applications of protein click chemistry.…”

Section: Introductionmentioning

confidence: 99%

Protein click chemistry and its potential for medical applications

Amiri,

Abedanzadeh,

Davaeil

et al. 2024

Quart. Rev. Biophys.

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A revolution in chemical biology occurred with the introduction of click chemistry. Click chemistry plays an important role in protein chemistry modifications, providing specific, sensitive, rapid, and easy-to-handle methods. Under physiological conditions, click chemistry often overlaps with bioorthogonal chemistry, defined as reactions that occur rapidly and selectively without interfering with biological processes. Click chemistry is used for the posttranslational modification of proteins based on covalent bond formations. With the contribution of click reactions, selective modification of proteins would be developed, representing an alternative to other technologies in preparing new proteins or enzymes for studying specific protein functions in different biological processes. Click-modified proteins have potential in diverse applications such as imaging, labeling, sensing, drug design, and enzyme technology. Due to the promising role of proteins in disease diagnosis and therapy, this review aims to highlight the growing applications of click strategies in protein chemistry over the last two decades, with a special emphasis on medicinal applications.

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Section: Introductionmentioning

confidence: 99%

Protein click chemistry and its potential for medical applications

Amiri,

Abedanzadeh,

Davaeil

et al. 2024

Quart. Rev. Biophys.

Self Cite

View full text Add to dashboard Cite

show abstract

“…27 Additionally, a series of water-based organic reactions accelerated by microwave [28][29][30] or ultrasound irradiation 31 occurred within minute scale times instead of days. Combination of the water-based organic synthesis 32 with the multi-component reactions 33,34 provided water-based MCRs 35 as a highlight division of green chemistry to produce the complex bioorganic molecules. Typically, water-based MCRs have developed as recent post-methods for the synthesis of various heterocyclic compounds.…”

Section: Introductionmentioning

confidence: 99%