Sustainable Green Methods for the Extraction of Biopolymers

Kumawat, Tarun Kumar; Kumawat, Varsha; Sharma, Swati; Sharma, Vishnu; Pandit, Anjali; Kandwani, Nirat; Biyani, Manish

doi:10.1007/978-3-030-98392-5_5

Cited by 8 publications

(1 citation statement)

References 283 publications

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“…The present results of this research is coherent with these ndings as it showed that the liver of diabetic rats had increased level of l i p i d p e r o x i d a t i o n , d e c r e a s e d G S H concentration, altered lipid prole and reduction in the activities of antioxidant enzymes such as glutathione peroxidase ( G P x ) , g l u t a t h i o n e r e d u c t a s e ( G R ) , glutathione transferase (GST), catalase and superoxide dismutase (SOD). The activities of these key endogenous antioxidant enzymes are inhibited during the oxidative stress induced by STZ (Kumawat et al, 2013). This suggests that antioxidants may play a vital role in the management of diabetes and its complications.…”

Section: Lipid Prolementioning

confidence: 99%

Hepato-Protective Role of Diphenyl Diselenide in Streptozotocininduced Diabetic Rats

Aanuoluwapo Patricia

2023

COAST

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Diabetic hepatopathy prevalence as a result of prolonged hyperglycemia is increasing with the expanding size of the diabetes population around the world. In this present study, the hepato-protective activity of diphenyl diselenide (DPDSe) in a persistent diabetic state was studied. Diabetes mellitus were induced with streptozotocin (STZ) (60 mg/kg) intraperitoneally and after 60 days without treatment, the rats were administered diphenyl dislenide (DPDSe) (10 mg/kg) orally for 35 days. Animals were euthanized liver and serum were used for experimental determinations such as glycemic level, non enzymic and enzymic redox statuses, hepatic biomarkers, hematological and lipid prole. The results showed that the fasting glucose levels and thiobarbituric reactive substances were reduced at a signicant level of p < 0.05. Furthermore, a concomitant rise in the percentage of DPPH free radicals scavenged, ferric reducing antioxidants property, protein and non-protein thiols were observed in hepatic tissue. The activities of delta–aminolevulinate dehydratase and antioxidant enzymes were improved at a signicant level of p < 0.05. Additionally, there was signicant reduction (p < 0.05) in the activity of the purinergic enzymes, hepatic biomarkers while there was an increase in the albumin level. Furthermore, the hematological and lipid prole of were refurbished. This study showed that DPDSe was able to reverse the biochemical alterations related with hepatic tissue in STZ-induced diabetic rats.

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Section: Lipid Prolementioning

confidence: 99%