The 2019 IEEE Eurasia Conference on Biomedical Engineering, Healthcare, and Sustainability (IEEE ECBIOS 2019) was held in Okinawa, Japan on 31 May–3 June 2019, and provided a unified communication platform for researchers in the fields of biomedical engineering, healthcare, and sustainability. Recently, healthcare has undergone a sector-wide transformation thanks to advances in computing, networking technologies, big data, and artificial intelligence. Healthcare is not only changing from being reactive and hospital-centered to preventive and personalized, but it is also changing from being disease focused to well-being centered. Healthcare systems, as well as fundamental medicine research, are becoming smarter and enabled in biomedical engineering. Furthermore, with cutting edge sensors and computer technologies, healthcare delivery could also yield better efficiency, higher quality, and lower cost. This Special Issue on “Selected Papers from the 2019 IEEE Eurasia Conference on Biomedical Engineering, Healthcare, and Sustainability (IEEE ECBIOS 2019)” is expected to select excellent papers that were presented in IEEE ECBIOS 2019 on the topic of sustainability. It will link several disciplines, including the environmental, cultural, economic, and social sustainability of human beings, which provide an advanced forum for studies related to sustainability and sustainable development. Our aim is to encourage scientists to publish their experimental and theoretical research relating to natural sciences, social sciences, and humanities in as much detail as possible in order to promote scientific predictions and impact assessments of global change and development.