Sustainable Nanotorus for Biosensing and Therapeutical Applications

Naseh, Md. Farhan; Ansari, Jamilur R.; Alam, Md Sabir; Javed, Md. Noushad

doi:10.1007/978-3-030-69023-6_47-1

Cited by 2 publications

(2 citation statements)

References 77 publications

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“…Sub-atomic docking results uncovered an exceptionally high intensity of compound given the protein-ligand interaction (PLI) profile, which was affirmed by a sub-atomic unique reproduction investigation. Thus, FA mitigating activity, which is connected to the presence of these bioactive mixtures (1-4), unequivocally upholds the plant's conventional use for irritation treatment [47][48][49][50][51] (Table 2). The potent antipancreatic cancer drug-lapachone is more bioavailable, effective, and toxic when it is complexed with HPβ-CD.…”

Section: Anti-inflammatory Activitymentioning

confidence: 96%

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

Mall

Yadav

Waziri

et al. 2022

Exploration of Medicine

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Fernandoa adenophylla (FA, Heterophragma adenophyllum) is a plant, cultivated throughout Africa and Southeast Asia. It contains potent phytochemicals such as novel naphthoquinones, their derivatives (peshwaraquinone, dilapachone, adenophyllone, indadone, and lapachol), and triterpenoids [ursolic acid (UA), β-sitosterol (BS), α-amyrin, and oleanolic acid (OA)] that have been assessed and reported to show potential pharmacological activities. The crude extract obtained from the plant has been investigated for certain pharmacological activities such as antibacterial, antifungal, anti-tubercular (TB), antihypertensive, and leishmanicidal activity. A novel drug delivery systems (NDDS) is the latest technique that combines innovative development, formulations, new technology, and methodologies for the safe delivery of pharmaceutical substances in the body. The present study reports the possible treatment opportunities of FA and recent possible novel drug delivery approaches for the natural medicinal phytochemicals.

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Section: Anti-inflammatory Activitymentioning

confidence: 96%

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

Mall

Yadav

Waziri

et al. 2022

Exploration of Medicine

View full text Add to dashboard Cite

show abstract

“…But of course, because of the small size and non-peptide nature they can lead to the development of molecule that can follow an alternate route with fewer side effects and more specific to the receptor [215][216][217][218][219][220][221]. In recent years, lots of review and research have been published on recent advancements of nanotechnology and their application on neurological disease as well as NP [222][223][224][225][226][227][228][229][230][231][232][233].…”

Section: Mechanism For Excitatory Effect Of Drugsmentioning

confidence: 99%

N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain

Choudhary

Kaur

Waziri

et al. 2023

Exploration of Medicine

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Neuropathic pain (NP) remains maltreated for a wide number of patients by the currently available treatments and little research has been done in finding new drugs for treating NP. Ziconotide (PrialtTM) had been developed as the new drug, which belongs to the class of ω-conotoxin MVIIA. It inhibits N-type calcium channels. Ziconotide is under the last phase of the clinical trial, a new non-narcotic drug for the management of NP. Synthetically it has shown the similarities with ω-conotoxin MVIIA, a constituent of poison found in fish hunting snails (Conus magus). Ziconotide acts by selectively blocking neural N-type voltage-sensitized Ca2+ channels (NVSCCs). Certain herbal drugs also have been studied but no clinical result is there and the study is only limited to preclinical data. This review emphasizes the N-type calcium channel inhibitors, and their mechanisms for blocking calcium channels with their remedial prospects for treating chronic NP.

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Sustainable Nanotorus for Biosensing and Therapeutical Applications

Cited by 2 publications

References 77 publications

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain

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