Effective leadership focused on sustainability is key to achieving operational excellence in a supply chain. Leaders with the right qualities implement sustainable practices throughout the chain, considering environmental, social, and economic factors. Success is influenced by company culture, stakeholder engagement, regulations, and data use. This approach leads to operational excellence with better efficiency, quality, and resilience, along with a competitive advantage and happy stakeholders. The framework is a roadmap for businesses to leverage leadership for a sustainable and successful supply chain.