Climate change and an increase in urbanization are severely testing urban drainage systems; at the same time, population growth is leading to an increase in demand for water resources, while climate change is more likely to reduce the amount of water that is available to meet this demand. The present study finds a solution to both problems by assuming a hybrid use of detention basins, i.e., providing a real-time control system (RTC) for the outfall discharge managed according to the rainfall forecast and the water level in the tank, to reuse rainwater for non-potable use and, at the same time, to guarantee the hydraulic protection of the downstream system. Twenty-seven scenarios were simulated using the numerical model SWMM 5.1, assuming different types of controls on the discharge. The simulations show a non-potable water-saving efficiency from a minimum of 32% to a maximum of 90%, and the reduction in volume discharged is between 11% and 31%, while the peak flow rate varies more significantly depending on the type of control used. These results highlight the detention basins’ potential deriving from the hybrid use of this system with rainwater harvesting systems.