2020
DOI: 10.1021/acssuschemeng.0c06751
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Sustainable Single-Stage Solid–Liquid Extraction of Hesperidin and Rutin from Agro-Products Using Cyrene

Abstract: Hesperidin and rutin are two sought-after natural flavonoids, traditionally extracted from abundant natural citrus fruits and tea leaves using large amounts of ethanol or methanol solvents. Recent trends in extractions have focused on minimizing the use of solvents and creating simpler cost-effective processes. This study aims to apply the concept of chemical valorization in the context of a circular economy, by using agro-industrial waste and biobased alternatives to traditional solvents, which are of environ… Show more

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Cited by 43 publications
(26 citation statements)
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“…Cyrene is known to form a symmetrical aldol condensation product in the presence of a base, as well as being sensitive to strong acids, which limits its use in certain applications. [15] Cyrene has been explored as bio‐based solvent in wire coatings, [16] filtration membranes industry,[ 17 , 18 ] pharmaceuticals, [19] graphene dispersion, [20] cross‐coupling, [21] polymers,[ 22 , 23 ] MOFs syntheses, [24] solvent extraction [25] or drug delivery [26] where it has replaced toxic polar aprotic solvents such as dichloromethane (DCM), N ‐methyl‐2‐pyrrolidone (NMP), N , N ’‐dimethylformamide (DMF) or N , N ’‐dimethylacetamide (DMAc).…”
Section: Introductionmentioning
confidence: 99%
“…Cyrene is known to form a symmetrical aldol condensation product in the presence of a base, as well as being sensitive to strong acids, which limits its use in certain applications. [15] Cyrene has been explored as bio‐based solvent in wire coatings, [16] filtration membranes industry,[ 17 , 18 ] pharmaceuticals, [19] graphene dispersion, [20] cross‐coupling, [21] polymers,[ 22 , 23 ] MOFs syntheses, [24] solvent extraction [25] or drug delivery [26] where it has replaced toxic polar aprotic solvents such as dichloromethane (DCM), N ‐methyl‐2‐pyrrolidone (NMP), N , N ’‐dimethylformamide (DMF) or N , N ’‐dimethylacetamide (DMAc).…”
Section: Introductionmentioning
confidence: 99%
“…At the current stage, a joint venture company between the Circa group and Norske Skog, FC5, has operated a 50 ton-per-annum (tpa) prototype plant for Cyrene that is produced by the hydrogenation of LGO in a batch different from the continuous Furacell process. The Circa group received authorization from the European Chemicals Agency (ECHA) to produce and import up to 100 tpa of Cyrene in the Europeaqn Union (EU) after receiving REACH Annex VIII approval 19 and is currently aiming to establish a 1000 tpa scale ReSolute plant with a grant from the EU's Horizon 2020 program. 91 Detailed information on the exact process for LGO production is lacking in the literature.…”
Section: ■ the Furacell Processmentioning
confidence: 99%
“…A key feature of this compound is its use as a solvent, reported for the first time in 2014 by Sherwood et al Because of its bioavailability, lower toxicity, biodegradability, and high performance as a dipolar aprotic solvent, it has already entered the marketplace and is expected to replace conventional N -methyl-2-pyrrolidone (NMP) and N , N -dimethylformamide (DMF), which will be restricted by Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) for industrial use. Cyrene is also used as a synthetic raw material and for extracting valuable bioactive compounds, such as hesperidin and rutin . Deeper hydrogenation converts LGO into levoglucosanol and then tetrahydrofurandimethanol (THFDM). , The hydrogenolysis products of THFDM, 1,2,6-hexanetriol and 1,6-hexanediol, are widely used in industry for polyester and polyurethane production.…”
Section: Introductionmentioning
confidence: 99%
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“…The use of renewable feedstocks and biobased solvents as replacement to commonly used petroleum-derived solvents is also promoted toward greener extraction processes [5]. Some recent examples can be highlighted in this sense, including, among others, Cyrene, a biobased solvent that has shown excellent extractability for bioactive compounds [6], or diethyl carbonate, used for enrichment of chlorophenols [7]. Alternatively, solvents such as deep eutectic solvents (DESs) and switchable polarity solvents (SPSs) are being used in sample preparation.…”
Section: Implementation Of Novel Materials In Sample Preparationmentioning
confidence: 99%