In this study, three full-scale experiments and a series of numerical simulations were conducted to investigate the influence of subway platform height and atrium ceiling height of subway stations on smoke control by mechanical exhausting systems. The smoke temperature variation with time, maximum temperature distribution, and smoke stratification were discussed. Results showed that the atrium had capacity to store smoke, especially at the early stage of smoke spread. However, the efficiency of smoke extraction did not increase simply with the rise in platform height and atrium ceiling height, and favorable smoke exhaust velocity was crucial for smoke elimination. The optimal smoke exhaust velocity was studied by numerical simulation and it was found that the area of smoke diffusion in subway stations with a higher platform was significantly smaller under the optimal smoke exhaust velocity. In addition, a prediction model of optimal smoke exhaust velocity with subway platform height was proposed. This study could provide on-site data and smoke spread characteristics for smoke control design, operation, and, significantly, guide safety evacuation of the exhaust system of subway stations.