Sustainable synthesis and applications of polyhydroxyalkanoates (PHAs) from biomass

Adeleye, Aderemi Timothy; Odoh, Chuks Kenneth; Enudi, Obieze C.; Banjoko, Oluwakemi Oluwabunmi; Osiboye, Osigbeminiyi Oludare; Odediran, Emmanuel Toluwalope; Louis, Hitler

doi:10.1016/j.procbio.2020.05.032

Cited by 119 publications

(69 citation statements)

References 187 publications

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“…However, not only are the chemicals used (e.g., concentrated acid) harmful to the environment, but the biomass refining process for higher yield could further contribute to the operation costs [80]. Thus, several pretreatments have been studied throughout the past and recent years (Table 6) [126]. According to Wang et al, pretreatment of newspaper and office waste resulted in an enormous increase in glucose output [127].…”

Section: Pretreatmentmentioning

confidence: 99%

Recent Advances in the Biosynthesis of Polyhydroxyalkanoates from Lignocellulosic Feedstocks

Vigneswari

Noor

Amelia

et al. 2021

Life

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Polyhydroxyalkanoates (PHA) are biodegradable polymers that are considered able to replace synthetic plastic because their biochemical characteristics are in some cases the same as other biodegradable polymers. However, due to the disadvantages of costly and non-renewable carbon sources, the production of PHA has been lower in the industrial sector against conventional plastics. At the same time, first-generation sugar-based cultivated feedstocks as substrates for PHA production threatens food security and considerably require other resources such as land and energy. Therefore, attempts have been made in pursuit of suitable sustainable and affordable sources of carbon to reduce production costs. Thus, in this review, we highlight utilising waste lignocellulosic feedstocks (LF) as a renewable and inexpensive carbon source to produce PHA. These waste feedstocks, second-generation plant lignocellulosic biomass, such as maize stoves, dedicated energy crops, rice straws, wood chips, are commonly available renewable biomass sources with a steady supply of about 150 billion tonnes per year of global yield. The generation of PHA from lignocellulose is still in its infancy, hence more screening of lignocellulosic materials and improvements in downstream processing and substrate pre-treatment are needed in the future to further advance the biopolymer sector.

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Section: Pretreatmentmentioning

confidence: 99%

Recent Advances in the Biosynthesis of Polyhydroxyalkanoates from Lignocellulosic Feedstocks

Vigneswari

Noor

Amelia

et al. 2021

Life

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“…The Halobactericeae, a family of bacteria, contains more than 300 bacteria sources for PHA synthesis. Pseudomonas oleovorans and Pseudomonas fragi are bacteria that can produce mcl PHAs through the beta (β) oxidation of alkanoic acids by producing hydroxyalkanoyl-CoA as a substrate [ 17 , 18 ]. Furthermore, PHAs containing 2-hydroxypropionate (2HP), 3-hydroxypropionate (3HP), 4-hydroxybutyrate (4HB), 3-hydroxyvalerate (3HV), and mcl 3-hydroxyalkanoate (3-HA) monomer units can all be produced by Escherichia coli via genes or exogenous and endogenous processes [ 19 , 20 , 21 ].…”

Section: Sources Of Phasmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Polyhydroxyalkanoates (PHAs): Biopolymers for Biofuel and Biorefineries

2021

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Fossil fuels are energy recourses that fulfill most of the world’s energy requirements. However, their production and use cause severe health and environmental problems including global warming and pollution. Consequently, plant and animal-based fuels (also termed as biofuels), such as biogas, biodiesel, and many others, have been introduced as alternatives to fossil fuels. Despite the advantages of biofuels, such as being renewable, environmentally friendly, easy to source, and reducing the dependency on foreign oil, there are several drawbacks of using biofuels including high cost, and other factors discussed in the fuel vs. food debate. Therefore, it is imperative to produce novel biofuels while also developing suitable manufacturing processes that ease the aforementioned problems. Polyhydroxyalkanoates (PHAs) are structurally diverse microbial polyesters synthesized by numerous bacteria. Moreover, this structural diversity allows PHAs to readily undergo methyl esterification and to be used as biofuels, which further extends the application value of PHAs. PHA-based biofuels are similar to biodiesel except for having a high oxygen content and no nitrogen or sulfur. In this article, we review the microbial production of PHAs, biofuel production from PHAs, parameters affecting the production of fuel from PHAs, and PHAs biorefineries. In addition, future work on the production of biofuels from PHAs is also discussed.

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“…Polyhydroxybutyrate synthase is an acyltransferase, the possibilities of which are studied in the context of the synthesis of poly-3-hydroxybutyrate (PHB), the most common member of the polyhydroxyalkanoate family [ 137 , 138 , 139 ]. Methods of microbiological synthesis of polyhydroxyalkanoates have become widespread, since polymers of this type are often used by bacteria as an intracellular source of carbon and energy [ 140 , 141 , 142 ]. There are also some recent studies on the synthesis of PHB from 3-hydroxybutyryl-CoA catalyzed by polyhydroxybutyrate synthase [ 75 ] and accompanied by propionyl-CoA transferase for regeneration of expensive coenzyme A [ 76 ].…”

Section: Enzymes and Polymers Produced With Themmentioning

confidence: 99%

Prospects of Using Biocatalysis for the Synthesis and Modification of Polymers

Nikulin

Švedas

2021

Molecules

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Trends in the dynamically developing application of biocatalysis for the synthesis and modification of polymers over the past 5 years are considered, with an emphasis on the production of biodegradable, biocompatible and functional polymeric materials oriented to medical applications. The possibilities of using enzymes not only as catalysts for polymerization but also for the preparation of monomers for polymerization or oligomers for block copolymerization are considered. Special attention is paid to the prospects and existing limitations of biocatalytic production of new synthetic biopolymers based on natural compounds and monomers from biomass, which can lead to a huge variety of functional biomaterials. The existing experience and perspectives for the integration of bio- and chemocatalysis in this area are discussed.

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Sustainable synthesis and applications of polyhydroxyalkanoates (PHAs) from biomass

Cited by 119 publications

References 187 publications

Recent Advances in the Biosynthesis of Polyhydroxyalkanoates from Lignocellulosic Feedstocks

Recent Advances in the Biosynthesis of Polyhydroxyalkanoates from Lignocellulosic Feedstocks

Polyhydroxyalkanoates (PHAs): Biopolymers for Biofuel and Biorefineries

Prospects of Using Biocatalysis for the Synthesis and Modification of Polymers

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